RDH11 Activators
RDH11 Activators encompass a variety of chemical compounds that directly or indirectly promote the functional activity of RDH11. Retinoic acid and its analogue isotretinoin (13-cis-Retinoic acid) act within the retinoid signaling pathway, enhancing RDH11's role in converting retinol to retinaldehyde, a critical step in the visual cycle and cellular differentiation. Beta-carotene further supports this function by serving as a precursor substrate, facilitating RDH11's enzymatic conversion to retinal. Fatty acids such as palmitic, linoleic, and oleic acid may modulate RDH11 activity by influencing the lipid membrane composition, which in turn could affect the enzyme's structural conformation and catalytic efficiency. Lecithin, through its choline and fatty acid content, also contributes to the maintenance of membrane integrity, potentially beneficial for the membrane-associated function of RDH11.
Additionally, dihydrolipoic acid could protect RDH11 from oxidative stress, maintaining enzyme activity, while essential cofactors like NAD+ and NADP+ are pivotal for RDH11's redox reactions, with their abundance facilitating the enzyme's catalysis. Zinc sulfate may enhance RDH11 by maintaining the enzyme's structural stability. Lastly, tretinoin, another form of vitamin A, indirectly augments RDH11 activity through its involvement in the retinoid signaling pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
RDH11 is involved in the metabolism of vitamin A. Retinoic acid upregulates RDH11 activity as part of the retinoid signaling pathway, enhancing the conversion of retinol to retinaldehyde. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
As an analogue of retinoic acid, isotretinoin can enhance RDH11 by promoting its role in the retinoid cycle, which is crucial for vision and cellular differentiation. | ||||||
β-Carotene | 7235-40-7 | sc-202485 sc-202485A sc-202485B sc-202485C | 1 g 25 g 50 g 5 kg | $80.00 $351.00 $621.00 $12791.00 | 5 | |
Beta-carotene serves as a substrate for RDH11 in the biosynthesis of retinal, indirectly increasing RDH11's functional activity in the process of vision. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
RDH11 has been shown to have affinity for fatty acids. Palmitic acid can influence RDH11 activity by altering the membrane lipid composition, thus potentially modifying enzyme function. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Lecithin is a source of choline and fatty acids, which are involved in maintaining cell membrane integrity, potentially affecting the membrane-associated activity of RDH11. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid, an essential fatty acid, can modulate the lipid environment of RDH11, thereby potentially enhancing its enzymatic activity related to retinoid metabolism. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid may affect RDH11 activity by altering membrane fluidity and thus influencing the protein’s conformation and catalytic efficiency. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
RDH11 uses NAD+ as a coenzyme in the oxidation-reduction reaction of retinol to retinaldehyde. Higher availability of NAD+ can thus enhance RDH11 activity. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
Similar to NAD+, NADP+ can serve as a cofactor for RDH11, and increased levels could indirectly enhance RDH11 catalytic function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a cofactor for many enzymes and is known to stabilize protein structures. It may enhance RDH11 activity by contributing to structural integrity. | ||||||