RBM23 Inhibitors

RBM23 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of RBM23, an RNA-binding protein involved in the regulation of RNA splicing. RBM23 plays a crucial role in pre-mRNA processing, particularly in the spliceosome, where it helps regulate the removal of introns and the joining of exons to produce mature mRNA transcripts. This process is vital for the accurate expression of genes, as improper splicing can lead to the production of dysfunctional or improperly regulated proteins. Inhibitors of RBM23 disrupt its ability to interact with RNA or other components of the spliceosome, thereby affecting the splicing machinery and leading to alterations in gene expression.

Studying RBM23 inhibitors allows researchers to investigate the role of this protein in the complex process of RNA splicing and how its inhibition impacts cellular functions. By blocking RBM23, scientists can explore the downstream effects on gene expression, as well as how splicing defects influence cellular processes like protein synthesis, cellular differentiation, and response to environmental stimuli. These inhibitors also provide insight into the specific interactions between RBM23 and other splicing factors, helping to clarify the molecular mechanisms that govern RNA splicing fidelity. Research on RBM23 inhibitors is essential for understanding how post-transcriptional regulation of gene expression is controlled and how disruptions in this process can lead to broader implications in cellular biology, including protein diversity and cellular adaptation to stress.