RBM22 Activators
RBM22 Activators are a diverse collection of chemical compounds that influence cellular pathways leading to the enhanced activity of RBM22, a pivotal component in RNA splicing. Compounds like Forskolin and A23187 elevate intracellular cAMP and calcium levels, respectively, which are crucial for kinase signaling pathways that can enhance the RNA binding and splicing functions of RBM22. Similarly, PMA's activation of PKC and Ionomycin's modulation of calcium-dependent kinases may result in altered phosphorylation states that favor RBM22's splicing activity. The inhibition of protein phosphatases by compounds such as Okadaic acid and Calyculin A can also lead to a hyperphosphorylated splicing machinery, potentially boosting RBM22's role in spliceosome assembly and function. Moreover, Spermine directly stabilizes RNA structures, possibly improving RBM22's RNA binding efficiency, while EGCG's kinase inhibition might indirectly benefit RBM22's splicing activity by affecting overall phosphorylation patterns within the cell.
In addition to these activators, compounds like Paclitaxel and Jaspisamide influence cytoskeletal dynamics and nuclear architecture, which may indirectly enhance the assembly and function of the spliceosome where RBM22 operates. Anisomycin, by inhibiting protein synthesis, has the potential to trigger cellular responses that upregulate post-transcriptional modifications, playing into the hands of RBM22's splicing activities. Lastly, 5-Azacytidine can alter gene expression patterns, which may indirectly lead to a cellular environment favoring the splicing roles of RBM22.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly raises intracellular cAMP levels which can enhance the activity of RBM22 by promoting the phosphorylation states that favor RBM22's RNA binding and splicing functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can influence the phosphorylation state of proteins involved in the same pathways as RBM22, possibly increasing RBM22's splicing activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which may enhance the activity of calcium-dependent kinases that phosphorylate substrates in the spliceosome where RBM22 operates. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid inhibits protein phosphatases 1 and 2A, which may lead to an increased phosphorylation state of components in the spliceosome, potentially enhancing RBM22's function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore, elevating intracellular calcium levels and potentially increasing RBM22 activity by affecting calcium-dependent signaling pathways involved in RNA splicing. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, like okadaic acid, inhibits protein phosphatases, leading to higher phosphorylation levels of splicing factors, which could enhance the splicing activity of RBM22. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that stabilizes the structure of RNA, which may enhance RBM22's ability to bind RNA and participate effectively in the splicing process. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several kinases, altering signaling pathways and phosphorylation patterns that may indirectly lead to an enhanced activity of RBM22 in splicing. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules, which may influence the localization and assembly of the spliceosome, potentially enhancing the splicing activity of RBM22. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jaspisamide modulates actin dynamics, which could indirectly influence nuclear architecture and enhance the activity of RBM22 by optimizing spliceosome assembly. | ||||||