Ran BP-2 Activators
Ran BP-2, also known as Ran-binding protein 2, is a cytoplasmic protein involved in the regulation of nucleocytoplasmic transport, cell cycle progression, and mitotic spindle assembly. It functions as a key component of the Ran GTPase cycle, which plays a central role in coordinating nucleocytoplasmic transport processes by regulating the transport of proteins and RNA molecules across the nuclear envelope. Ran BP-2 interacts with the small GTPase Ran, acting as a Ran effector protein to modulate its activity and function. Through its association with Ran, Ran BP-2 participates in various cellular processes, including the import of nuclear proteins into the nucleus, the export of RNA and ribosomal subunits from the nucleus to the cytoplasm, and the regulation of mitotic spindle assembly and dynamics.
The activation of Ran BP-2 is intricately regulated by multiple mechanisms that control its subcellular localization and interaction with binding partners. One key mechanism of Ran BP-2 activation involves the binding of Ran-GTP to its Ran-binding domain (RBD), leading to a conformational change that enhances its affinity for other proteins and enables its participation in nucleocytoplasmic transport processes. Additionally, post-translational modifications such as phosphorylation and SUMOylation have been implicated in regulating the activity and function of Ran BP-2. Phosphorylation events, catalyzed by specific kinases, can modulate the stability, localization, and interaction dynamics of Ran BP-2, thereby influencing its activity in nucleocytoplasmic transport and mitotic spindle assembly. Furthermore, the SUMOylation of Ran BP-2 has been shown to regulate its nuclear import and export functions, highlighting the importance of post-translational modifications in controlling the activity of this critical cellular protein. Understanding the mechanisms underlying Ran BP-2 activation is essential for elucidating its roles in cellular processes and their implications for normal physiology and disease states.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid is a direct activator of Ran BP-2 by binding to its receptor RAR, leading to enhanced Ran BP-2 expression and nuclear translocation. | ||||||
Xanthohumol from hop (Humulus lupulus) | 6754-58-1 | sc-301982 | 5 mg | $354.00 | 1 | |
Xanthohumol indirectly activates Ran BP-2 by inhibiting the proteasomal degradation pathway, resulting in increased Ran BP-2 protein levels. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin indirectly activates Ran BP-2 by stimulating cAMP production, which activates PKA, leading to enhanced Ran BP-2 phosphorylation and function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol indirectly activates Ran BP-2 by binding to β-adrenergic receptors and activating cAMP/PKA signaling, promoting Ran BP-2 phosphorylation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol indirectly activates Ran BP-2 by modulating the SIRT1 pathway, which affects Ran BP-2 acetylation and its nucleocytoplasmic shuttling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride indirectly activates Ran BP-2 by inhibiting GSK-3β, leading to enhanced Ran BP-2 phosphorylation and nuclear localization. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 indirectly activates Ran BP-2 by inducing intracellular calcium release, which influences Ran BP-2 and its transport functions. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram indirectly activates Ran BP-2 by inhibiting PDE4, increasing cAMP levels, and stimulating Ran BP-2 phosphorylation via PKA activation. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 indirectly activates Ran BP-2 through PPARδ, which regulates Ran BP-2 expression and its involvement in nuclear transport processes. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP indirectly activates Ran BP-2 by mimicking cAMP, stimulating PKA and enhancing Ran BP-2 phosphorylation and nuclear transport. | ||||||