Rad53 Inhibitors
Rad53 inhibitors represent a class of chemical compounds designed to target and modulate the activity of the Rad53 protein kinase, a key player in the DNA damage response pathway. The DNA damage response is a critical cellular mechanism that safeguards the integrity of the genome by detecting and repairing damaged DNA strands. Rad53, also known as CHK2 in humans, is a conserved protein kinase that functions as a central regulator in this pathway. When DNA damage occurs, Rad53 is activated and phosphorylates a variety of downstream targets, leading to cell cycle arrest, DNA repair, and, in some cases, cell death to prevent the propagation of damaged genetic material. Rad53 inhibitors, therefore, serve as valuable research tools for investigating the intricacies of the DNA damage response pathway and its implications in cellular biology.
These inhibitors are designed to interfere with Rad53's kinase activity, preventing its ability to phosphorylate downstream targets. By inhibiting Rad53, researchers can gain insights into the specific functions of this protein and its role in DNA repair and cell cycle regulation. Additionally, Rad53 inhibitors are valuable in understanding the fundamental biology of DNA damage response, which has implications in various fields, including cancer research, genetic studies, and the development of novel strategies for combating diseases related to DNA damage and repair. Researchers employ Rad53 inhibitors in laboratory settings to decipher the underlying molecular mechanisms involved in DNA damage response and explore avenues for the development of targeted interventions in the future.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine has been shown to influence various cellular processes and may have the potential to modulate the expression of proteins involved in the DNA damage response, possibly including Rad53, although its exact mechanism of action in this context is not clear. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, has been reported to affect the expression of various genes and proteins. Its potential to inhibit Rad53 expression could be related to its ability to modulate cellular stress response pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound found in grapes and berries, has been studied for its ability to influence cell cycle and DNA repair mechanisms, potentially impacting the expression of Rad53 through these pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, and it has been shown to influence various signaling pathways in cells. Its role in inhibiting Rad53 expression may be linked to its ability to modulate cellular responses to DNA damage. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
L-Sulforaphane, found in cruciferous vegetables, is known for its role in activating antioxidant response pathways. It may potentially inhibit Rad53 expression by influencing cellular defense mechanisms against oxidative stress. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a well-known inhibitor of the mTOR pathway, which plays a role in cell growth and proliferation. By modulating this pathway, rapamycin could potentially influence the expression of Rad53. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin hydrochloride intercalates into DNA and disrupts replication. While it induces DNA damage, its complex effects on cell signaling pathways could potentially influence the expression of Rad53 in a context-dependent manner. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor, leading to DNA damage. It has the potential to modulate various DNA damage response pathways, possibly influencing Rad53 expression as part of the cellular response to the damage it induces. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, resulting in decreased deoxyribonucleotide levels and replication stress. This stress could potentially modulate the expression of Rad53 as the cell responds to the challenge. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is incorporated into RNA and DNA, causing damage and disrupting normal cellular processes. Its impact on DNA replication and repair pathways could potentially influence the expression of Rad53. | ||||||