Rab 3 GAP p150 Activators
Rab3 GTPase-activating protein p150 (Rab3 GAP p150) is a significant component of the Rab3 GTPase-activating protein complex. This protein complex plays a crucial role in the regulation of exocytosis, a process vital for the release of neurotransmitters and hormones. The Rab3 GAP complex is specifically composed of two subunits: the catalytic p130 subunit and the non-catalytic p150 subunit.The p150 subunit of Rab3 GAP is particularly important for the localization and function of the complex. It helps in targeting the complex to specific membrane compartments within the cell, thereby ensuring the precise regulation of exocytosis. This subunit contains a Rab3-binding domain, which is essential for its interaction with Rab3 GTPases. This interaction is crucial for the proper functioning of the Rab3 GAP complex, as it enables the complex to accelerate the conversion of Rab3 GTPases from their active GTP-bound form to their inactive GDP-bound form.
This regulation of Rab3 GTPases by Rab3 GAP p150 is vital for the control of vesicle trafficking, particularly in neurons and endocrine cells. By modulating the activity of Rab3 GTPases, the Rab3 GAP complex, with its p150 subunit, plays a key role in the timing and specificity of vesicle fusion events at the plasma membrane.Furthermore, research has suggested that disruptions in the function of Rab3 GAP, including the p150 subunit, may be linked to certain neurological disorders. This highlights the importance of Rab3 GAP p150 in not only normal cellular processes but also in the context of disease pathology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
GTPγS is a non-hydrolyzable analogue of GTP. It can indirectly activate Rab3 by binding and maintaining GTP-bound Rab proteins in an active state, which may subsequently influence Rab 3 GAP p150 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can modulate signaling pathways that may indirectly affect Rab 3 GAP p150 function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC). PKC signaling can indirectly influence Rab3 activity and thus may impact Rab 3 GAP p150. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially affecting calcium-dependent signaling pathways linked to Rab3 and Rab 3 GAP p150. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
A cAMP analogue that activates PKA, potentially influencing signaling pathways that affect Rab 3 GAP p150. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
A selective PKC inhibitor, Gö6976 might influence signaling pathways that indirectly modulate Rab 3 GAP p150 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
An inhibitor of phosphoinositide 3-kinases, LY294002 may affect signaling pathways related to Rab 3 GAP p150. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibitor of mTOR, Rapamycin can influence signaling pathways that indirectly impact Rab 3 GAP p150 function. | ||||||