PYROXD2 Inhibitors
PYROXD2 inhibitors are a class of chemical compounds that target the enzyme pyridine nucleotide-disulfide oxidoreductase domain 2 (PYROXD2). This enzyme is part of the oxidoreductase family, which plays a critical role in the regulation of oxidative-reductive processes within the cell. Inhibitors that focus on PYROXD2 are designed to interact with the active site or other relevant regions of the enzyme to impede its normal function. This interruption can alter the enzyme's ability to catalyze the transfer of electrons from one molecule to another, a fundamental biochemical process. The specificity of these inhibitors is crucial; they must selectively bind to PYROXD2 without affecting the myriad of other oxidoreductases that operate in cellular environments. The molecular architecture of PYROXD2 inhibitors often includes reactive groups that are capable of forming covalent or non-covalent bonds with amino acid residues within the enzyme's active site.
The development of these inhibitors relies heavily on an understanding of the enzyme's structure and the key interactions that occur during its catalytic cycle. Advanced techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and computational modeling are often utilized to determine the three-dimensional structure of PYROXD2, which helps in identifying potential binding sites for inhibitors. Once identified, medicinal chemists can design molecules that fit these sites with high affinity and specificity. These inhibitors may possess various chemical features, such as rings structures, heteroatoms, and double bonds, which enable them to occupy the active site of PYROXD2 snugly, mimicking the enzyme's natural substrates or products to prevent its normal activity. The precise interaction between an inhibitor and PYROXD2 can include hydrogen bonding, hydrophobic interactions, and van der Waals forces, among others. These interactions are finely tuned to ensure that the inhibitor effectively blocks the enzyme's function without destabilizing its overall structure or interacting with other cellular components.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 (CoQ10) is an essential component in the mitochondrial electron transport chain. By supplementing with CoQ10, the redox state in the mitochondria can be altered, potentially affecting the function of PYROXD2, assuming PYROXD2's involvement in oxidative processes. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Allopurinol is a xanthine oxidase inhibitor. Since xanthine oxidase is involved in the production of reactive oxygen species (ROS), allopurinol can decrease oxidative stress, which may indirectly influence PYROXD2 if it plays a role in the cellular response to ROS. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. The inhibition of complex I can lead to reduced cellular respiration and a lowered production of ROS. If PYROXD2 is related to redox reactions in cells, this decrease in ROS production could indirectly inhibit PYROXD2’s function. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $265.00 | 2 | |
Atovaquone selectively inhibits the cytochrome bc1 complex in mitochondria. Its inhibition leads to the disruption of electron transport and decreased ATP synthesis. If PYROXD2 is involved in mitochondrial energetics, atovaquone could indirectly influence its function by altering mitochondrial ATP levels. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin is an inhibitor of the mitochondrial ATP synthase (complex V). It blocks the proton channel, which is necessary for ATP synthesis. This inhibition could influence PYROXD2 if its function is linked to ATP levels or the proton gradient across the mitochondrial membrane. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
This compound is a chelator of divalent metal cations and can inhibit certain metalloenzymes. If PYROXD2 is a metal-dependent enzyme, this chelation could impede its catalytic activity by removing essential metal cofactors. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A is an inhibitor of the cytochrome c reductase (complex III) in the electron transport chain. This compound would disrupt the mitochondrial electron flow, which could indirectly affect PYROXD2 if it interacts with the electron transport chain or associated redox reactions. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits cytochrome c oxidase (complex IV) by binding to the heme cofactor in the enzyme. The inhibition of complex IV disrupts the mitochondrial electron transport chain, which could interfere with PYROXD2's activity if it is associated with mitochondrial respiration. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $148.00 $133.00 $311.00 $397.00 $925.00 $1801.00 | 24 | |
This compound is an inhibitor of NADPH oxidases which are involved in generating ROS. By inhibiting ROS production, it could potentially affect PYROXD2 if the protein is part of cellular mechanisms responding to oxidative stress. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Tetracycline can inhibit mitochondrial protein synthesis as it binds to the 30S subunit of mitochondrial ribosomes. Inhibiting mitochondrial protein synthesis could indirectly affect PYROXD2 if it relies on mitochondrial-encoded proteins or is involved in mitochondrial translation. | ||||||