Date published: 2026-2-14

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Ptpn23 Activators

Ptpn23 Activators refer to a distinct group of chemical agents aimed at enhancing the activity of Protein Tyrosine Phosphatase Non-Receptor Type 23 (PTPN23), a member of the protein tyrosine phosphatase family that dephosphorylates tyrosine residues on proteins. The activity of PTPN23 is critical for various cellular processes, including the regulation of signal transduction pathways, cellular growth, and intracellular trafficking. As activators, these compounds would be expected to increase the catalytic action of PTPN23, which could be achieved by promoting a conformational state that favors substrate interaction, augmenting the enzyme's stability, or increasing its expression levels. These activators might bind directly to the enzyme, possibly at allosteric sites, to enhance its overall phosphatase activity or could indirectly lead to upregulated expression of the PTPN23 gene, thereby raising the intracellular concentration of the enzyme.

Investigating the mode of action of Ptpn23 activators would involve detailed biochemical analyses and structural biology techniques. Kinetic assays would be utilized to define the effects of these activators on the enzyme's activity, providing insights into changes in enzymatic parameters such as substrate affinity (K_M) and catalytic rate (k_cat). These studies would help to ascertain whether the activators influence the enzyme by modifying its interaction with substrates or by accelerating the dephosphorylation reaction. Moreover, researchers might employ advanced imaging methods, like X-ray crystallography or cryo-electron microscopy, to visualize the interaction between PTPN23 and its activators at an atomic level, identifying the binding sites and elucidating the induced conformational changes. Such structural data, complemented by molecular docking and dynamic simulation studies, would be instrumental in guiding the development of new compounds with enhanced potency and specificity for PTPN23. Additionally, cellular approaches might be taken to examine the impact of these activators on the expression and cellular distribution of PTPN23, further clarifying the effects these molecules have on the enzyme's physiological function.

SEE ALSO...

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

EGCG can modulate various signaling pathways and may influence gene expression related to signal transduction.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

As a tyrosine kinase inhibitor, genistein may affect PTP expression as part of a compensatory cellular response.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

A metabolite of Vitamin A, retinoic acid influences gene expression and might affect Ptpn23 as part of developmental signaling.

3,3′-Diindolylmethane

1968-05-4sc-204624
sc-204624A
sc-204624B
sc-204624C
sc-204624D
sc-204624E
100 mg
500 mg
5 g
10 g
50 g
1 g
$37.00
$65.00
$89.00
$421.00
$681.00
$66.00
8
(1)

A compound found in cruciferous vegetables that can modulate AhR signaling, potentially affecting gene expression.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

As a histone deacetylase inhibitor, it can cause chromatin remodeling and affect the expression of various genes.

Adenosine 3′,5′-cyclic monophosphate

60-92-4sc-217584
sc-217584A
sc-217584B
sc-217584C
sc-217584D
sc-217584E
100 mg
250 mg
5 g
10 g
25 g
50 g
$116.00
$179.00
$265.00
$369.00
$629.00
$1150.00
(1)

A cAMP analog that may alter gene expression by activating protein kinase A (PKA) signaling pathways.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

As a diacylglycerol analog, PMA activates protein kinase C (PKC) and can influence signaling pathways and gene expression.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

Known to activate Nrf2, which is involved in the cellular response to oxidative stress and may affect gene expression.

Zearalenone

17924-92-4sc-204943
sc-204943A
10 mg
50 mg
$120.00
$369.00
6
(1)

It acts as an estrogen receptor agonist and could modulate gene expression through hormone receptor pathways.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

As a polyphenol, resveratrol can modulate several signaling pathways, including those that may affect gene expression.