PTN Activators
PTN activators constitute a diverse class of chemicals capable of positively modulating the expression and function of Pleiotrophin (PTN). Lithium Chloride and Lithium Carbonate directly activate PTN by inhibiting GSK-3β, leading to the activation of the Wnt/β-catenin signaling pathway. Retinoic Acid activates PTN through the retinoic acid receptor (RAR), initiating downstream signaling cascades that positively influence PTN expression and function, including pathways such as MAPK and PI3K/Akt. Forskolin and Dibutyryl cAMP, direct activators of PTN, mimic the effects of increased intracellular cAMP levels, positively influencing PTN expression and function through pathways like PKA. Trichostatin A, an HDAC inhibitor, directly activates PTN by enhancing histone acetylation and chromatin accessibility, leading to altered gene expression and cellular responses.
SB216763, an inhibitor of GSK-3β, activates PTN through the Wnt/β-catenin signaling pathway, similar to Lithium compounds. Rosiglitazone activates PTN through PPARγ, influencing pathways such as MAPK and PI3K/Akt. 8-Bromo-cGMP mimics the effects of NO, increasing intracellular cGMP levels and positively influencing PTN expression and function through pathways like PKG. Indirect activators such as Bay K8644 and Ionomycin modulate PTN expression and function by increasing intracellular calcium levels, impacting pathways like CAMKII and PKC. Indomethacin, an inhibitor of COX, indirectly activates PTN by decreasing prostaglandin synthesis, affecting various signaling pathways dependent on PTN activity. Y-27632, an inhibitor of ROCK, indirectly activates PTN through pathways like MAPK and PI3K/Akt by modulating GTPases. This diverse array of PTN activators highlights the complexity of the regulatory mechanisms governing PTN expression and function. Understanding how these chemicals modulate specific signaling pathways provides crucial insights into the intricate cellular responses influenced by PTN activity.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a direct activator of PTN. It activates the retinoic acid receptor (RAR), initiating downstream signaling cascades that positively influence PTN expression and function. This activation occurs through RAR-mediated pathways, such as MAPK and PI3K/Akt, leading to the modulation of cellular responses dependent on PTN activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a direct activator of PTN. It activates adenylate cyclase, leading to an increase in intracellular cAMP levels. This rise in cAMP positively influences PTN expression and function through pathways such as PKA, leading to the modulation of cellular responses dependent on PTN activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride is a direct activator of PTN. It activates the Wnt/β-catenin signaling pathway, positively influencing PTN expression and function. The activation occurs through the inhibition of GSK-3β, leading to the stabilization and nuclear translocation of β-catenin, which modulates cellular responses dependent on PTN activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a direct activator of PTN. It inhibits histone deacetylases (HDACs), leading to increased histone acetylation and chromatin accessibility. This positively influences PTN expression and function, modulating cellular responses through epigenetic regulation and altered gene expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a direct activator of PTN. As a cell-permeable cAMP analog, it mimics the effects of Forskolin by increasing intracellular cAMP levels. This rise in cAMP positively influences PTN expression and function through pathways such as PKA, leading to the modulation of cellular responses dependent on PTN activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is a direct activator of PTN. It inhibits GSK-3β, activating the Wnt/β-catenin signaling pathway and positively influencing PTN expression and function. The stabilization and nuclear translocation of β-catenin modulate cellular responses dependent on PTN activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone is a direct activator of PTN. It activates peroxisome proliferator-activated receptor gamma (PPARγ), initiating downstream signaling cascades that positively influence PTN expression and function. This activation occurs through PPARγ-mediated pathways, such as MAPK and PI3K/Akt, leading to the modulation of cellular responses dependent on PTN activity. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $104.00 $354.00 | 7 | |
8-Bromo-cGMP is a direct activator of PTN. As a cell-permeable cGMP analog, it mimics the effects of Nitric Oxide (NO) by increasing intracellular cGMP levels. This rise in cGMP positively influences PTN expression and function through pathways such as PKG, leading to the modulation of cellular responses dependent on PTN activity. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 is an indirect activator of PTN. It activates L-type calcium channels, leading to increased intracellular calcium levels. This rise in calcium positively influences PTN expression and function through pathways such as CAMKII and PKC, modulating cellular responses dependent on PTN activity. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin is an indirect activator of PTN. It inhibits cyclooxygenases (COX), leading to decreased prostaglandin synthesis. This inhibition positively influences PTN expression and function, as prostaglandins can modulate cellular responses through various signaling pathways, including MAPK and PI3K/Akt, dependent on PTN activity. | ||||||