PSM Activators

The chemical class of PSM activators comprises a diverse array of compounds that can influence the expression or activity of PSM through various cellular pathways. Forskolin, for instance, acts as an activator of adenylate cyclase, leading to increased intracellular cAMP levels. This elevation in cAMP can activate protein kinase A (PKA), which may modulate PSM through downstream signaling pathways, influencing cellular growth and differentiation. PMA (Phorbol 12-myristate) is a phorbol ester that activates protein kinase C (PKC), impacting various cellular processes. PKC-mediated pathways can influence PSM through the modulation of transcription factors and other signaling molecules. Dibutyryl cAMP, a cell-permeable analog of cAMP, directly elevates intracellular cAMP levels, activating PKA and influencing PSM expression or activity through downstream signaling cascades. A23187, a calcium ionophore, facilitates the influx of calcium into cells. Elevated intracellular calcium levels can activate calcium-dependent signaling pathways, modulating PSM through calcium-sensitive processes. 6-Benzylaminopurine, a synthetic cytokinin, influences cell division and differentiation, impacting PSM through cellular processes related to growth and differentiation.

Retinoic Acid, as a ligand for nuclear retinoic acid receptors (RARs), modulates gene expression and may influence PSM through retinoic acid-responsive elements in the genome. DHPG (Dihydroxyphenylglycine), a selective agonist for metabotropic glutamate receptors (mGluRs), can influence PSM through the modulation of intracellular signaling cascades. Bay K 8644, a dihydropyridine calcium channel activator, enhances calcium influx, leading to the activation of signaling pathways and transcription factors that may impact PSM. N6-Cyclopentyladenosine, a selective adenosine A1 receptor agonist, modulates intracellular signaling pathways and influences PSM through the downstream effects of adenosine receptor activation. Ionomycin, a calcium ionophore similar to A23187, facilitates calcium influx into cells, modulating PSM through calcium-sensitive processes. GW0742, a synthetic agonist for peroxisome proliferator-activated receptor delta (PPARδ), can influence PSM through the modulation of gene expression and related signaling pathways.