PSG20 Inhibitors
PSG20 inhibitors are a class of chemical compounds designed to inhibit the activity or expression of the protein PSG20 (Pregnancy-Specific Glycoprotein 20). PSG20 belongs to a family of glycoproteins involved in various biological processes, particularly within the immune system. As members of the immunoglobulin superfamily, PSG proteins are known for their ability to modulate immune signaling and cell-cell interactions. The structure of PSG20 features multiple immunoglobulin-like domains, which are believed to play a role in binding to other proteins or cellular receptors. PSG20 inhibitors are typically small molecules or biologics that are designed to interact with the protein's active sites or key structural domains, preventing it from participating in normal biological pathways. The mechanisms by which these inhibitors operate can vary; some may function by competitive inhibition at ligand-binding domains, while others may induce allosteric changes that disrupt PSG20's conformation or function.
The chemical properties of PSG20 inhibitors are generally tailored to optimize binding affinity, specificity, and stability. These compounds may include modifications to enhance cell permeability and bioavailability or to improve their resistance to enzymatic degradation. Structural analyses of PSG20 and its inhibitors often involve crystallography or other biophysical techniques to determine key interaction points and to facilitate rational drug design. The inhibition of PSG20 can have various effects on biological pathways related to immune regulation, cellular adhesion, and signal transduction. By selectively targeting PSG20, researchers aim to dissect its biological role in cellular processes and understand the molecular mechanisms behind its function. Consequently, PSG20 inhibitors serve as valuable tools in biochemical and molecular biology studies to explore the role of PSG20 in various cellular contexts without reference to any clinical applications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Actin polymerization inhibitor disrupting phagocytosis. By binding to actin monomers, Latrunculin A prevents actin filament assembly, indirectly inhibiting Psg20 function in phagocytic processes by impeding cytoskeletal dynamics essential for engulfment. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor affecting the PI3K/Akt pathway. Alters phagocytosis indirectly by disrupting downstream signaling, impacting Psg20-mediated processes. Wortmannin interferes with PI3K-regulated events critical for efficient phagocytosis, contributing to the inhibition of Psg20 activity. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Actin polymerization inhibitor interfering with phagocytosis. By binding to the growing ends of actin filaments, Cytochalasin D disrupts actin dynamics, indirectly inhibiting Psg20-mediated processes by preventing cytoskeletal rearrangements crucial for phagocytic engulfment. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor impacting the PI3K/Akt pathway. Alters phagocytosis indirectly by impeding PI3K-mediated signaling, disrupting downstream events crucial for Psg20 function. LY294002 influences cytoskeletal dynamics and intracellular signaling, contributing to the inhibition of Psg20 activity. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Myosin II inhibitor affecting the actin-myosin interaction. Indirectly modulates Psg20-mediated phagocytosis by disrupting myosin-dependent contractility, altering cytoskeletal dynamics and impairing the efficiency of engulfment processes. Blebbistatin interferes with the molecular machinery essential for Psg20 function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor disrupting TGF-β signaling. Indirectly influences Psg20 by interfering with TGF-β-mediated pathways, potentially affecting cellular processes related to phagocytosis. SB431542 alters downstream events crucial for Psg20 function, contributing to the indirect inhibition of phagocytic processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor disrupting the JNK signaling pathway. Indirectly influences Psg20 by altering the JNK cascade, potentially impacting cellular processes related to phagocytosis. SP600125 modulates downstream effectors crucial for Psg20 function, contributing to the indirect inhibition of phagocytic processes. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
DNA-damaging agent potentially affecting phagocytosis. While the mechanism is not fully elucidated, Bleomycin's impact on DNA structure may lead to indirect modulation of Psg20 activity, affecting cellular processes involved in phagocytosis through as-yet-uncharacterized pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Rho kinase inhibitor affecting actin dynamics. Alters phagocytosis indirectly by disrupting Rho kinase-regulated events, impacting cytoskeletal rearrangements crucial for Psg20-mediated processes. Y-27632 interferes with the molecular machinery essential for efficient phagocytic engulfment, contributing to Psg20 inhibition. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Actin polymerization stabilizer affecting phagocytosis. By promoting actin filament stability, Jasplakinolide indirectly influences Psg20-mediated processes by enhancing cytoskeletal dynamics crucial for efficient engulfment. The compound stabilizes the molecular machinery essential for Psg20 function, contributing to its inhibition. | ||||||