PRPSAP2 Inhibitors

PRPSAP2 inhibitors Methotrexate and Mycophenolic acid target enzymes involved in the folate pathway and purine synthesis, which are essential for nucleotide generation. By inhibiting these pathways, these compounds can decrease the demand for PRPSAP2's regulatory functions. 6-Mercaptopurine and Azathioprine get incorporated into nucleic acids, disrupting their normal metabolism and indirectly influencing the cellular environment in which PRPSAP2 operates.

Hydroxyurea, Clofarabine, and Fludarabine are inhibitors of ribonucleotide reductase, an enzyme critical for the synthesis of deoxyribonucleotides, thereby potentially affecting the availability of substrates regulated by PRPSAP2. 5-Fluorouracil disrupts pyrimidine metabolism, which is closely linked to the purine synthesis pathway where PRPSAP2 is implicated. Allopurinol modifies purine catabolism, which can lead to changes in the levels of purine nucleotides and influence PRPSAP2 indirectly. Ribavirin, a broad-spectrum antiviral agent, interferes with the synthesis of guanine nucleotides, impacting the balance of nucleotide pools that PRPSAP2 might help regulate. Cladribine and Didanosine are analogs that interfere with nucleotide synthesis and function, which can lead to a reduced need for PRPSAP2's role in nucleotide biosynthesis regulation.