PP2Cε Inhibitors
PP2Cε inhibitors belong to a specialized category of chemical compounds designed to target and modulate the activity of PP2Cε, which stands for Protein Phosphatase 2C epsilon. PP2Cε is a member of the PP2C family of serine/threonine phosphatases, which are enzymes that play essential roles in cellular signaling and regulation. These phosphatases are involved in the dephosphorylation of various target proteins, thereby influencing diverse cellular processes, including cell growth, stress responses, and signal transduction pathways. Inhibitors of PP2Cε are developed to interact with this specific enzyme, influencing its catalytic activity, substrate specificity, or its participation in cellular processes where PP2Cε is involved.
Structurally, PP2Cε inhibitors are meticulously designed to engage specific regions or binding sites on the PP2Cε protein. This interaction may disrupt the normal functioning of PP2Cε, affecting its ability to dephosphorylate target proteins or its involvement in signaling cascades. The mechanisms by which PP2Cε inhibitors exert their effects can vary, but their primary objective is to serve as valuable tools for researchers studying the roles of PP2Cε in various cellular contexts. Investigating the biochemical and functional aspects of PP2Cε and its modulation by inhibitors can contribute to a deeper understanding of serine/threonine phosphatase signaling, cellular regulation, and the broader field of molecular and cellular biology. Ultimately, such research can offer insights into the intricate molecular mechanisms that govern fundamental cellular functions and their regulation by PP2Cε.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
A potent inhibitor of protein phosphatases. It can inhibit PP2Cε by blocking its catalytic activity, leading to enhanced phosphorylation of substrates. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
A toxin known to inhibit serine/threonine protein phosphatases. It might inhibit PP2Cε by binding to its active site. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
While primarily known as an immunosuppressant, it also inhibits some protein phosphatases. It might influence PP2Cε's activity indirectly. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
An inhibitor of protein phosphatases. It can inhibit PP2Cε by preventing its dephosphorylation activity. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $113.00 | 2 | |
A derivative of cantharidin with similar phosphatase inhibitory activity. It can potentially inhibit PP2Cε's function. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $265.00 | 9 | |
Known to inhibit several protein phosphatases. It can bind to PP2Cε and prevent it from dephosphorylating its substrates. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $49.00 $203.00 | 1 | |
An herbicide that also acts as a protein phosphatase inhibitor. It can inhibit PP2Cε by binding to its catalytic domain. | ||||||
Sodium perchlorate, anhydrous | 7601-89-0 | sc-203398 sc-203398A sc-203398B | 100 g 500 g 2.5 kg | $66.00 $204.00 $627.00 | ||
Known to inhibit some protein phosphatases. It might affect the activity of PP2Cε, leading to changes in phosphorylation dynamics in the cell. | ||||||