POU6F2 Activators
POU6F2 Activators are a specialized class of chemical compounds that exhibit a unique ability to modulate the activity of the POU6F2 transcription factor. POU6F2, also known as POU class 6 homeobox 2, is a crucial transcription factor involved in the regulation of gene expression and plays a pivotal role in various cellular processes. The activation of POU6F2 by these compounds is of significant interest to researchers in the field of molecular biology and genetics.
These activators are typically small molecules that interact with POU6F2 in a specific manner, leading to the enhancement of its transcriptional activity. This modulation of POU6F2 function can have profound effects on gene expression patterns within a cell, ultimately influencing cellular processes and responses. While the exact mechanisms of action of POU6F2 activators may vary depending on the specific compound, they often work by binding to POU6F2 or its associated proteins, thereby promoting its binding to target DNA sequences and facilitating the recruitment of other co-factors involved in transcriptional regulation. This enhanced activity can result in the upregulation of genes that are under the control of POU6F2, impacting cellular differentiation, development, or other vital functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which activates PKA. PKA can phosphorylate transcription factors and coactivators that interact with POU6F2, potentially enhancing its transcriptional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator. PKC phosphorylation of proteins in the vicinity of POU6F2 might alter the local chromatin structure or coactivator availability, facilitating POU6F2's binding and function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, activating calcium-dependent signaling pathways that may lead to post-translational modifications of POU6F2 or its co-regulators, enhancing POU6F2 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit certain kinases, potentially reducing competition for coactivators or the phosphorylation state of inhibitory proteins that regulate POU6F2's activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. Inhibition of PI3K can modulate signaling pathways, potentially relieving an inhibitory control on POU6F2 and thus enhancing its activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression through its receptors, which might interact with POU6F2 to co-regulate target genes, thereby enhancing POU6F2's transcriptional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, which can lead to a more open chromatin state and might enhance POU6F2's access to DNA, increasing its functional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can lead to hyperacetylation of histones and a more accessible chromatin state for transcription factors such as POU6F2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore, which can increase intracellular calcium and activate calcium-dependent signaling, potentially enhancing the activity of POU6F2. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine has been found to induce autophagy and can also influence epigenetic regulation, which might impact the cellular context in which POU6F2 operates, indirectly enhancing its activity. | ||||||