POLR2B Inhibitors
POLR2B inhibitors belong to a specific chemical class of compounds that have been studied and designed to selectively target and inhibit the activity of POLR2B, which stands for RNA Polymerase II Subunit B. POLR2B is an essential subunit of RNA polymerase II, the enzyme responsible for transcribing messenger RNA (mRNA) from DNA in eukaryotic cells. Inhibition of POLR2B aims to disrupt the function of RNA polymerase II, leading to the downregulation of mRNA transcription and potentially affecting gene expression. The chemical structures of POLR2B inhibitors can vary, including synthetic small-molecule compounds and natural products that specifically interact with POLR2B and hinder its enzymatic activity or assembly into the RNA polymerase II complex.
Researchers have explored various strategies to target POLR2B and modulate mRNA transcription, which is crucial for various cellular processes, including protein synthesis and cellular regulation. The study of POLR2B inhibitors provides valuable insights into the complex regulatory mechanisms governing gene transcription and cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Alpha-amanitin is a toxic compound found in certain species of mushrooms and is a potent inhibitor of RNA polymerase II, including its POLR2B subunit. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a natural compound found in a traditional Chinese medicinal plant, which has shown inhibitory effects on RNA polymerase II activity, including POLR2B. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D is an antibiotic that can bind to DNA and RNA, leading to the inhibition of RNA polymerases, including POLR2B. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is a synthetic compound that has been used as a research tool to inhibit RNA polymerase II activity, including POLR2B. | ||||||