POLR2B Activators
In this context, the term activators is used to describe compounds that can potentially influence POLR2B activity, primarily through indirect mechanisms. These chemicals do not directly activate POLR2B but affect transcriptional dynamics or cellular processes that are crucial for POLR2B's role in transcription.DRB and α-Amanitin, known for their inhibitory effects on RNA polymerase II, can paradoxically enhance POLR2B activity under certain conditions by triggering cellular compensatory mechanisms.
Histone deacetylase inhibitors like Trichostatin A (TSA) and SAHA (Vorinostat) are used to increase chromatin accessibility, which could potentially enhance the function of POLR2B by facilitating transcriptional processes. Bromodomain inhibitors (JQ1 and I-BET151) and DNA methyltransferase inhibitors (such as RG108) modify the chromatin state, potentially impacting POLR2B function by altering transcription regulation. BAY 11-7082, as an NF-κB pathway inhibitor, represents a compound that can indirectly affect POLR2B through changes in cellular signaling pathways.Other compounds like Flavopiridol (a CDK9 inhibitor), SGC0946 (a DOT1L inhibitor), and UNC1999 (an EZH2 inhibitor) can influence chromatin structure and transcriptional regulation, potentially affecting POLR2B activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor, promoting a more open chromatin state, potentially enhancing POLR2B function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA, a histone deacetylase inhibitor, may indirectly increase POLR2B activity by improving transcriptional machinery access to DNA. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a BET bromodomain inhibitor, might indirectly influence POLR2B activity by altering transcription regulation. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a BET inhibitor that can modulate transcriptional activity, potentially affecting POLR2B. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits the NF-κB pathway, potentially indirectly influencing POLR2B through cellular signaling changes. | ||||||
1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose | 6974-32-9 | sc-220477 | 1 g | $122.00 | ||
5'-Deoxy-5-fluorouridine is a nucleoside analog that can alter transcription and might indirectly affect POLR2B activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108, a DNA methyltransferase inhibitor, may influence chromatin structure and transcription, potentially affecting POLR2B. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol, a CDK9 inhibitor, while generally reducing transcription, may have complex effects that influence POLR2B in certain contexts. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is an inhibitor of EZH2, part of the PRC2 complex, potentially altering transcription and indirectly affecting POLR2B. | ||||||