PLSCR5 Inhibitors
PLSCR5 inhibitors are a class of chemical compounds designed to target and inhibit phospholipid scramblase 5 (PLSCR5), a member of the phospholipid scramblase family, which plays a critical role in the movement of phospholipids between the inner and outer leaflets of the cell membrane. Phospholipid scramblases, including PLSCR5, are involved in the regulation of membrane asymmetry, which is essential for numerous cellular processes, such as cell signaling, membrane repair, and apoptosis. PLSCR5 specifically is thought to regulate lipid distribution and membrane dynamics in specialized tissues, contributing to the maintenance of membrane integrity and the coordination of signaling pathways. By inhibiting PLSCR5, these compounds interfere with the enzyme's ability to mediate phospholipid translocation, potentially altering membrane structure and function.
The mechanism by which PLSCR5 inhibitors function involves binding to the enzyme, preventing it from interacting with phospholipids and disrupting the normal scramblase activity. This inhibition can have a broad impact on cellular processes that depend on the dynamic rearrangement of membrane lipids, including signal transduction, vesicle trafficking, and membrane fusion events. Researchers use PLSCR5 inhibitors to study the enzyme's specific role in lipid homeostasis and membrane biology, exploring how scramblase activity influences the overall structure and function of the plasma membrane. These inhibitors offer a valuable tool for investigating how the disruption of phospholipid asymmetry affects cellular signaling and membrane-related processes, contributing to a deeper understanding of the regulation of lipid dynamics and the role of PLSCR5 in maintaining cellular architecture and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol inhibits the β-adrenergic receptor, which can lead to decreased cAMP levels in the cell. Lower cAMP may inhibit Phospholipid scramblase family member 5 by reducing protein kinase A activity, which is known to phosphorylate and regulate the activity of various proteins including scramblases. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits tyrosine kinases, which are involved in the activation of signal transduction pathways that can regulate scramblase activity. By inhibiting these kinases, Genistein can reduce the phosphorylation and thus inhibit the activation of Phospholipid scramblase family member 5. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
Calphostin C inhibits protein kinase C (PKC). Since PKC can phosphorylate a wide range of proteins, its inhibition can lead to the functional inhibition of Phospholipid scramblase family member 5, assuming PKC directly or indirectly influences its phosphorylation state. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Rottlerin is known to inhibit protein kinase C delta (PKCδ). If PKCδ is involved in the activation of Phospholipid scramblase family member 5, then its inhibition by Rottlerin would result in the functional inhibition of this scramblase. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 Hydrochloride is a calmodulin antagonist. By inhibiting calmodulin, W-7 Hydrochloride can inhibit calcium-dependent signaling pathways, potentially inhibiting the activation and function of calcium-dependent proteins such as Phospholipid scramblase family member 5. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Gö 6983 is an inhibitor of protein kinase C (PKC) isoforms. By inhibiting PKC activity, Gö 6983 can reduce the phosphorylation of proteins that may include Phospholipid scramblase family member 5, leading to its functional inhibition. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a selective inhibitor of protein kinase C. By inhibiting PKC, Chelerythrine could inhibit the phosphorylation and thus the activation of proteins involved in membrane dynamics, including Phospholipid scramblase family member 5. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I inhibits protein kinase C. By preventing PKC from phosphorylating its substrate proteins, this inhibitor can lead to the functional inhibition of proteins regulated by PKC, potentially including Phospholipid scramblase family member 5. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). By inhibiting MLCK, ML-7 can disrupt cytoskeletal dynamics and cellular processes that depend on it, potentially leading to the functional inhibition of membrane-associated proteins such as Phospholipid scramblase family member 5. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a non-selective kinase inhibitor. As kinases regulate the activity of a wide array of proteins, the broad-spectrum inhibition by Staurosporine could result in the decreased phosphorylation and functional inhibition of proteins such as Phospholipid scramblase family member 5. | ||||||