PLC β4 Activators
The class of chemicals known as PLC β4 Activators encompasses a diverse array of compounds that can either directly or indirectly modulate the activity of Phospholipase C beta 4 (PLC β4), a key enzyme involved in cellular signaling. These activators offer unique insights into the regulation of PLC β4 and its role in orchestrating downstream signaling cascades. DiC8-PIP2, a synthetic analog of phosphatidylinositol 4,5-bisphosphate (PIP2), stands out as a direct activator by serving as a substrate for PLC β4. Upon cellular uptake, DiC8-PIP2 interacts with PLC β4, initiating hydrolysis and generating second messengers, highlighting the significance of specific lipid substrates in activating PLC β4. This direct activation provides a molecular basis for understanding the tight regulation of PLC β4 activity in response to changes in cellular lipid composition.
Furthermore, m-3M3FBS, a synthetic compound acting as a non-hydrolyzable analog of inositol trisphosphate (IP3), directly activates PLC β4 by mimicking the action of the endogenous second messenger. This pharmacological tool offers precise control over PLC β4 activity, facilitating the investigation of its downstream effects on cellular processes. The indirect activators, such as AlF4-, the βγ-subunits of G-proteins, and RhoA GTPase, showcase the integration of PLC β4 into complex signaling networks. These compounds act by modulating the GPCR signaling pathway or interacting with small G-proteins, indirectly influencing PLC β4 activity and providing a nuanced perspective on the regulatory mechanisms governing this enzyme. In addition, lipids such as Oleic Acid, Arachidonic Acid, and Lysophosphatidic Acid (LPA) indirectly activate PLC β4 by influencing the cellular lipid environment. Their incorporation into membrane phospholipids or binding to specific receptors initiates signaling cascades that converge on PLC β4, emphasizing the interconnected nature of lipid signaling and PLC β4-mediated cellular responses. Overall, the PLC β4 Activators class showcases the intricate regulation of PLC β4 activity by both direct substrate interactions and indirect signaling events.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Oleoyl lysophosphatidic acid | 65528-98-5 | sc-222720 sc-222720A sc-222720B sc-222720C | 1 mg 5 mg 10 mg 25 mg | $32.00 $142.00 $250.00 $541.00 | 11 | |
1-Oleoyl lysophosphatidic acid indirectly activates PLC β4 by modulating lipid membrane composition. Through its incorporation into cellular membranes, 1-Oleoyl lysophosphatidic acid influences the biophysical properties of the lipid bilayer, potentially enhancing the membrane association and activity of PLC β4. | ||||||
1-O-Oleyl-rac-glycerol | 111-03-5 | sc-201999 | 1 g | $301.00 | ||
1-oleoyl-rac-glycerol, a monoacylglycerol, indirectly activates PLC β4 by serving as a lipid mediator. Through its interaction with PLC β4, 1-oleoyl-rac-glycerol may influence the enzyme's conformation or membrane association, leading to enhanced enzymatic activity. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid, a polyunsaturated fatty acid, indirectly activates PLC β4 by acting as a signaling lipid. Arachidonic Acid can be released from membrane phospholipids and serve as a direct or indirect activator by influencing the lipid environment surrounding PLC β4. | ||||||
m-3M3FBS | 200933-14-8 | sc-202217 sc-202217A | 10 mg 50 mg | $141.00 $630.00 | 10 | |
m-3M3FBS is a synthetic compound that directly activates PLC β4 by binding to its catalytic domain. Acting as a non-hydrolyzable analog of inositol trisphosphate (IP3), m-3M3FBS mimics the action of IP3 and induces a conformational change in PLC β4, resulting in increased enzymatic activity. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid, a monounsaturated fatty acid, indirectly activates PLC β4 by modulating cellular lipid composition. Incorporation of Oleic Acid into membrane phospholipids may influence the biophysical properties of the lipid bilayer, impacting the membrane association and activity of PLC β4. | ||||||
1,2-Dioleoyl-sn-glycerol | 24529-88-2 | sc-204958 sc-204958A | 10 mg 25 mg | $114.00 $170.00 | ||
1,2-Dioleoyl-sn-glycerol is a direct activator of PLC β4. DAG directly binds to the C1 domain of PLC β4, inducing a conformational change that enhances the enzyme's catalytic activity. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Lysophosphatidic Acid (LPA), a bioactive lipid, indirectly activates PLC β4 by binding to its G-protein-coupled receptors (LPA receptors). Upon LPA receptor activation, G-proteins are activated, leading to the subsequent activation of PLC β4. | ||||||