PLC β2 Activators
PLC β2 activators represent a diverse array of compounds that can modulate the activity of Phospholipase C beta 2 (PLC β2), a key enzyme involved in intracellular signaling. PLC β2 plays a crucial role in cellular responses by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG). The identified compounds can either directly activate PLC β2 or indirectly influence its activity through intricate signaling pathways. One notable activator is ET-18-OCH3, a sphingosine derivative that activates PLC β2 by influencing sphingosine-1-phosphate (S1P) signaling. S1P activates PLC β2 through G protein-coupled receptors, illustrating a potential indirect modulation mechanism. U-73122, a PLC inhibitor, suggests that its structural analogs might have PLC-activating properties, offering insights into potential indirect activation strategies.
DiC8, a diacylglycerol analog, directly activates PLC β2 by mimicking the action of endogenous diacylglycerol. This compound induces the hydrolysis of PIP2, initiating downstream cellular responses. Additionally, growth factors like EGF and vasoactive peptides such as VIP and bombesin activate PLC β2 through GPCR signaling, providing direct insights into the modulation of PLC β2 by diverse extracellular signals. Muscarinic agonists like carbachol and acetylcholine, as well as other GPCR agonists like bradykinin, thrombin, and histamine, directly activate PLC β2 by initiating G protein signaling cascades. These compounds shed light on the intricate regulation of PLC β2 by neurotransmitters, kinins, and coagulation factors. In summary, PLC β2 activators encompass a range of compounds that directly or indirectly modulate the activity of PLC β2, offering insights into the regulation of this crucial enzyme in cellular signaling. These activators impact pathways such as sphingolipid signaling, GPCR signaling, and growth factor signaling, collectively highlighting the multifaceted nature of PLC β2 activation and its role in orchestrating diverse cellular responses.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $50.00 $75.00 $260.00 $505.00 | 3 | |
Angiotensin II activates PLC β2 through G protein-coupled receptor (GPCR) signaling. By binding to its receptor, angiotensin II triggers G protein activation, subsequently leading to the activation of PLC β2 and the hydrolysis of PIP2, modulating cellular responses associated with angiotensin II signaling. | ||||||
Bombesin | 31362-50-2 | sc-397365 | 1 mg | $79.00 | ||
Bombesin activates PLC β2 through GPCR signaling. Upon binding to its receptor, bombesin induces G protein activation, subsequently leading to the activation of PLC β2 and hydrolysis of PIP2. This direct activator sheds light on the role of neuropeptides in modulating PLC β2 and associated cellular responses. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $120.00 $275.00 $380.00 $670.00 $1400.00 $3000.00 | 12 | |
Carbachol, a muscarinic agonist, activates PLC β2 through GPCR signaling. By binding to muscarinic receptors, carbachol induces G protein activation, subsequently leading to the activation of PLC β2 and hydrolysis of PIP2. This direct activator provides insights into cholinergic signaling and associated cellular responses. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates PLC β2 through GPCR signaling. Upon binding to its receptor, bradykinin induces G protein activation, subsequently leading to the activation of PLC β2 and hydrolysis of PIP2. This direct activator provides insights into the role of kinins in modulating PLC β2 and associated cellular responses. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $230.00 | ||
Thrombin activates PLC β2 through GPCR signaling. Binding of thrombin to its receptor induces G protein activation, leading to the activation of PLC β2 and hydrolysis of PIP2. This direct activator offers insights into the role of coagulation factors in modulating PLC β2 and associated cellular responses. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine activates PLC β2 through GPCR signaling. Binding of histamine to its receptor induces G protein activation, leading to the activation of PLC β2 and hydrolysis of PIP2. This direct activator provides insights into the role of biogenic amines in modulating PLC β2 and associated cellular responses. | ||||||