Date published: 2025-9-18

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plasminogen Inhibitors

Plasminogen inhibitors belong to a specialized class of compounds that play a crucial role in regulating the activity of the enzyme plasminogen. Plasminogen is an inactive precursor of plasmin, a serine protease that plays a pivotal role in the dissolution of blood clots, tissue remodeling, and various physiological processes involving the breakdown of proteins. Plasminogen inhibitors are substances or molecules that can modulate the conversion of plasminogen into its active form, plasmin, by preventing its activation through proteolytic cleavage. These inhibitors serve as key players in maintaining the delicate balance between clot formation and clot dissolution within the human body. Plasminogen inhibitors can be categorized into several subtypes based on their mechanisms of action. Some inhibitors target specific enzymes, such as tissue-type plasminogen activator (tPA) or urokinase-type plasminogen activator (uPA), which are responsible for converting plasminogen into plasmin. By interfering with the activation of these enzymes, these inhibitors can indirectly regulate the overall plasmin activity. Others may directly interact with plasminogen itself, hindering its conformational changes required for activation. Understanding the precise mechanisms of action of these inhibitors is crucial in elucidating their physiological roles and implications in various pathological conditions. Further research in this area is essential for unraveling the intricate regulatory pathways involving plasminogen inhibitors and their relevance to health.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

TLCK hydrochloride

4238-41-9sc-201296
200 mg
$160.00
2
(1)

TLCK hydrochloride acts as a selective inhibitor of plasminogen activation, showcasing a unique affinity for the serine protease domain. Its interaction with the enzyme is characterized by the formation of a covalent bond, which alters the conformation of the active site, thereby hindering substrate access. This compound exhibits distinct reaction kinetics, with a rapid association phase followed by a slower dissociation, underscoring its effectiveness in modulating fibrinolytic pathways.

Benzamidine Hydrochloride

206752-36-5sc-207323
sc-207323A
sc-207323B
sc-207323C
sc-207323D
sc-207323E
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$46.00
$107.00
$270.00
$500.00
$1158.00
$2254.00
(1)

Benzamidine Hydrochloride serves as a potent inhibitor of plasminogen activation, demonstrating a strong binding affinity for the active site of serine proteases. Its unique structural features facilitate specific hydrogen bonding and electrostatic interactions, which stabilize the enzyme-inhibitor complex. The compound exhibits notable reaction kinetics, characterized by a fast initial binding followed by a gradual equilibrium, effectively influencing proteolytic activity and modulating fibrinolytic processes.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Dexamethasone may downregulate the expression of plasminogen by interacting with glucocorticoid receptors, leading to changes in gene transcription.

p-APMSF, Hydrochloride

74938-88-8sc-204155
sc-204155A
sc-204155B
sc-204155C
5 mg
10 mg
50 mg
100 mg
$85.00
$109.00
$299.00
$560.00
1
(1)

p-APMSF, Hydrochloride is a selective inhibitor of serine proteases, exhibiting unique molecular interactions that disrupt the catalytic activity of plasminogen. Its structure allows for specific hydrophobic interactions and steric hindrance, which effectively block substrate access to the active site. The compound's reaction kinetics reveal a rapid association phase, followed by a slower dissociation, highlighting its potential to finely tune proteolytic pathways and influence cellular signaling mechanisms.

Camostat mesylate

59721-29-8sc-203867
sc-203867A
sc-203867B
sc-203867C
sc-203867D
sc-203867E
10 mg
50 mg
500 mg
1 g
10 g
100 g
$42.00
$179.00
$306.00
$612.00
$2040.00
$4386.00
5
(0)

Camostat mesylate acts as a modulator of plasminogen activity through its ability to interact with serine proteases. Its unique structure facilitates specific binding interactions that alter the conformational dynamics of the enzyme, impacting substrate recognition. The compound exhibits distinct reaction kinetics, characterized by a fast initial binding phase, which transitions into a prolonged stabilization of the enzyme-inhibitor complex, thereby influencing proteolytic regulation and cellular processes.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin is known to exhibit anti-inflammatory properties and may influence various signaling pathways, potentially leading to the suppression of plasminogen expression.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol can modulate multiple signaling pathways and has been shown to have anti-inflammatory effects, which might contribute to the downregulation of plasminogen expression.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin inhibits the mTOR pathway, which is involved in cell growth and proliferation, and this inhibition could extend to the downregulation of plasminogen expression.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

(-)-Epigallocatechin Gallate is a major catechin in green tea and has been studied for its anti-inflammatory and antioxidant properties, which might influence plasminogen expression.

Indomethacin

53-86-1sc-200503
sc-200503A
1 g
5 g
$28.00
$37.00
18
(1)

Indomethacin is a compound that may influence plasminogen expression through its effects on inflammation and related pathways.