PIGF Inhibitors
PIGF inhibitors are a class of compounds designed to target and inhibit the activity of the PIGF (Phosphatidylinositol Glycan Anchor Biosynthesis, Class F) enzyme. PIGF plays a crucial role in the GPI (glycosylphosphatidylinositol) anchor biosynthesis pathway, which is essential for the attachment of certain proteins to the cell membrane. Specifically, PIGF is involved in the transfer of an ethanolamine phosphate group to the glycan core during the early stages of GPI anchor formation. This modification is critical for the proper assembly and function of GPI anchors, which serve to localize and stabilize proteins on the cell surface. By inhibiting PIGF, researchers can disrupt the GPI anchor biosynthesis process, providing a tool to study the biological roles of GPI-anchored proteins in cell function.
PIGF inhibitors are valuable in experimental settings, allowing researchers to explore the impact of GPI anchor deficiencies on cellular processes. By blocking PIGF function, these inhibitors prevent the synthesis of functional GPI anchors, leading to the mislocalization of proteins that depend on GPI anchoring for their membrane association. This disruption can affect various cellular pathways, including signal transduction, cell-cell interactions, and immune responses. PIGF inhibitors provide a means to investigate how cells adapt to the absence of GPI-anchored proteins, shedding light on the broader biological roles of this class of proteins. Additionally, by studying the effects of PIGF inhibition, researchers gain insights into the mechanisms of GPI anchor assembly and its importance in maintaining the structural and functional integrity of the cell membrane. This research helps in understanding the critical role of GPI anchors in a wide range of cellular activities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac may reduce PIGF expression by inhibiting the nuclear factor-kappa B (NF-κB) signaling pathway, which is associated with the transcriptional activation of PIGF. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could decrease PIGF expression by downregulating the activity of transcription factors like NF-κB and STAT3, which are involved in the upregulation of PIGF under pro-inflammatory conditions. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin might diminish PIGF expression by hindering the phosphorylation of signal transducer and activator of transcription 3 (STAT3), a promoter of PIGF transcription in response to growth factors and cytokines. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could downregulate PIGF expression by impeding the ERK1/2 pathway, which plays a role in transmitting growth signals that can lead to increased PIGF transcription. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide could downregulate PIGF expression by inducing DNA damage responses that lead to cell cycle arrest, thereby limiting the transcription of genes involved in angiogenesis, including PIGF. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol may suppress PIGF expression by stabilizing microtubules, which results in disrupted cell division and attenuated release of pro-angiogenic signals needed for PIGF transcription. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide likely leads to reduced PIGF expression through the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is a potent activator of PIGF gene transcription. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin might suppress PIGF expression by activating AMPK, which can lead to the inhibition of mTORC1 signaling and subsequent downregulation of HIF-1α-mediated PIGF transcription under hypoxic conditions. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is likely to inhibit PIGF expression by directly binding to mTORC1, thereby halting downstream angiogenic processes that contribute to the transcriptional activation of PIGF. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib may lead to decreased PIGF expression by targeting the ABL kinase, disrupting downstream signaling cascades that are required for the transcription of angiogenic factors, including PIGF. | ||||||