PIG-N Inhibitors
PIG-N inhibitors, as a class, primarily focus on chemicals that have an indirect effect on the functionality of the PIG-N protein by targeting the GPI-anchor biosynthesis pathway. The GPI-anchor is a glycolipid that attaches various proteins to the cell membrane, and PIG-N is integral to its synthesis. By disrupting the processes involved in GPI biosynthesis, these inhibitors can consequently influence the activity of PIG-N.
A significant portion of these inhibitors, like Manumycin A and Tipifarnib, target the farnesylation process, which is essential for GPI-anchor synthesis. Others, such as Tunicamycin and Swainsonine, interfere with glycosylation processes, specifically affecting the glycan component of GPI anchors. Given that the GPI-anchor biosynthesis occurs in the endoplasmic reticulum (ER), agents like Brefeldin A, which disrupt protein trafficking between the ER and the Golgi apparatus, can also influence PIG-N's role. Furthermore, several inhibitors, including Miltefosine, Myriocin, and D-PDMP, impact lipid synthesis and metabolism, crucial for the lipid nature of GPI anchors.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Farnesyltransferase inhibitor. Farnesylation is essential for GPI-anchor synthesis. Manumycin A can impair this process, thus influencing the function of PIG-N involved in the GPI biosynthesis. | ||||||
Tipifarnib | 192185-72-1 | sc-364637 | 10 mg | $720.00 | ||
A farnesyltransferase inhibitor, similar to Manumycin A, it hinders the farnesylation process crucial for GPI-anchor synthesis, subsequently affecting PIG-N activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
An inhibitor of N-linked glycosylation. Given that GPI anchor has a glycan component, disruption in glycosylation can influence PIG-N's role in forming GPI anchors. | ||||||
Phytic acid solution | 83-86-3 | sc-205806 sc-205806A | 100 ml 500 ml | $148.00 $505.00 | ||
Alpha-mannosidase inhibitor. By targeting mannosylation, it affects the synthesis of the glycan component of GPI anchors, which can indirectly affect PIG-N. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disturbs protein trafficking between the ER and Golgi apparatus. Given that GPI anchor biosynthesis occurs in the ER, disruption of this transport can influence PIG-N functionality. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Akt inhibitor. Akt signaling has roles in cell survival and metabolism, and its inhibition may affect multiple pathways, including those that might indirectly interact with GPI biosynthesis and PIG-N. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $79.00 | 8 | |
An alkylphospholipid that can disrupt lipid-dependent processes. Given the lipid nature of GPI anchors, Miltefosine can potentially affect PIG-N's role in GPI biosynthesis. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $106.00 | 8 | |
Inhibits serine palmitoyltransferase, key for sphingolipid synthesis. As lipid synthesis is crucial for GPI anchors, Myriocin can indirectly influence PIG-N. | ||||||
R-(+)-Etomoxir | 124083-20-1 | sc-208201A sc-208201 | 2 mg 5 mg | $245.00 $430.00 | ||
Inhibits carnitine palmitoyltransferase-1, an enzyme in fatty acid metabolism. This can impact the lipid component of GPI anchors and indirectly modulate PIG-N's function. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
Inhibits fatty acid synthase. Given the lipid nature of GPI anchors, disruption in fatty acid synthesis can indirectly influence the function of PIG-N. | ||||||