PIG-K Activators
Phosphatidylinositol glycan anchor biosynthesis class K protein (PIG-K), also known as Gpi8, is a protein that in humans is encoded by the PIGK gene. This protein is an integral part of the GPI transamidase complex, which is involved in the attachment of proteins to the cell surface via glycosylphosphatidylinositol (GPI) anchors.
GPI anchors are glycolipids that attach to the C-terminus of specific proteins, enabling them to anchor to the cell membrane. They play a crucial role in various biological processes, including signal transduction, protein sorting, and cell-cell interactions.PIG-K/Gpi8, as a component of the GPI transamidase complex, is involved in the final step of GPI anchoring. It cleaves the GPI anchor precursor at its preformed signal peptide, and simultaneously transfers the protein to the exposed GPI structure. The resulting GPI-anchored protein can then be transported to the cell surface.Defects in other parts of the GPI anchor biosynthesis pathway have been linked to a group of disorders known as GPI-anchor deficiencies, which can have wide-ranging effects, from developmental delay to epilepsy.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi structure and function, potentially affecting GPI-anchor biosynthesis where PIG-K is involved. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine inhibits mannosidase II, an enzyme in the Golgi, which might indirectly influence PIG-K related pathways. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that alters Golgi function and could impact processes related to GPI-anchor biosynthesis. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, which could indirectly affect GPI-anchor biosynthesis and PIG-K activity. | ||||||
D-Mannoheptulose | 3615-44-9 | sc-221499A sc-221499 sc-221499B sc-221499C sc-221499D | 25 mg 50 mg 100 mg 250 mg 500 mg | $261.00 $474.00 $915.00 $1851.00 $3692.00 | 1 | |
Mannosamine is an inhibitor of mannosylation, a process potentially linked to GPI-anchor synthesis and PIG-K function. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
As an analog of Coenzyme Q10, it might influence mitochondrial function, potentially impacting cellular processes including those involving PIG-K. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin inhibits fatty acid synthase, potentially affecting lipid metabolism and indirectly GPI-anchor biosynthesis. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Fenretinide affects lipid metabolism and might have indirect implications for GPI-anchor biosynthesis and PIG-K activity. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Triacsin C inhibits acyl-CoA synthetase, potentially influencing lipid metabolism linked with GPI-anchor biosynthesis. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
U18666A is an inhibitor of cholesterol trafficking, which might indirectly affect GPI-anchor biosynthesis involving PIG-K. | ||||||