PIF1 Activators
PIF1 activators belong to a distinct chemical class that has garnered considerable attention within the realm of molecular biology and cellular processes. These compounds are specifically designed to interact with and modulate the activity of the PIF1 helicase enzyme. PIF1, short for "Petite Integration Frequency 1," is a highly conserved helicase found in various organisms, including yeast and humans. Its primary function is to unwind and resolve DNA structures, playing a pivotal role in processes like DNA replication, repair, and recombination. PIF1 activators are synthetic or naturally occurring molecules that have been identified for their unique ability to enhance the helicase activity of PIF1.
At a molecular level, PIF1 activators typically function by binding to PIF1's active site or allosteric sites, inducing conformational changes that increase the enzyme's unwinding efficiency. By doing so, these activators facilitate the unwinding of DNA structures, including G-quadruplexes and other challenging secondary structures, which are known to impede normal DNA replication and repair. This enhanced helicase activity can have far-reaching implications in cellular processes, as it ensures the timely and accurate duplication and maintenance of the genetic material. Moreover, PIF1 activators have found utility as invaluable research tools in elucidating the intricate mechanisms underlying DNA metabolism, providing insights into genome stability and the intricate dynamics of DNA-protein interactions. Their utility in both basic research and potential applications beyond the laboratory underscores the significance of PIF1 activators in advancing our understanding of fundamental cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which is known to enhance the helicase activity of PIF1 by deacetylating it. This leads to the functional activation of PIF1, improving its role in DNA unwinding and repair mechanisms, thus directly enhancing its activity in cellular DNA maintenance and stability. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a cofactor for sirtuins, including SIRT1, which indirectly activates PIF1 by improving its enzymatic activity through deacetylation processes. Increased NAD+ levels enhance SIRT1 activity, which in turn activates PIF1 by promoting its DNA repair and replication functions. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine has been shown to activate AMP-activated protein kinase (AMPK), which indirectly influences cellular energy balance and could enhance the activity of proteins involved in DNA repair, including PIF1. Through AMPK activation, berberine promotes cellular responses that favor PIF1 activation in DNA repair pathways. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMPK, a master regulator of cellular energy homeostasis, which can indirectly enhance the activity of DNA repair enzymes, including PIF1. By activating AMPK, metformin supports cellular mechanisms that favor the functional activation of PIF1 in genomic stability and repair. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, has been shown to activate SIRT1, which is involved in the deacetylation of various proteins, including those involved in DNA repair processes. Through SIRT1 activation, quercetin can indirectly activate PIF1, enhancing its role in DNA unwinding and repair. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN, a precursor of NAD+, boosts SIRT1 activity, which in turn can activate PIF1 by improving its enzymatic functions related to DNA repair and replication. This indirect activation pathway underscores the role of NAD+ metabolism in supporting PIF1's DNA maintenance roles. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is known to induce autophagy and can enhance the activity of sirtuins, including SIRT1, which indirectly activates PIF1 by promoting DNA repair mechanisms. Through the activation of sirtuins, spermidine supports the functional activation of PIF1 in cellular longevity and DNA stability. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin activates sirtuin pathways, including SIRT1, which plays a crucial role in deacetylating and activating PIF1. By enhancing SIRT1 activity, fisetin indirectly supports the activation of PIF1, facilitating its function in DNA unwinding and repair processes. | ||||||
Pterostilbene, Pterocarpus marsupium | 537-42-8 | sc-203223 sc-203223A | 10 mg 100 mg | $211.00 $1196.00 | ||
Pterostilbene, similar to resveratrol, activates SIRT1, which is known to facilitate the activation of PIF1 by deacetylation. This activation process emphasizes pterostilbene's role in enhancing PIF1's function in genomic maintenance and stability through sirtuin-mediated pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane has been shown to activate Nrf2, which can indirectly support the activation of DNA repair proteins, including PIF1, by enhancing cellular antioxidant responses and reducing oxidative stress, a condition that necessitates robust DNA repair mechanisms. | ||||||