PHTF1 Activators
Chemicals classified as PHTF1 Activators have the potential to enhance the functional activity of the transcription factor PHTF1 through various cellular and molecular mechanisms. Forskolin, through its activation of adenylate cyclase, leads to an increase in intracellular cAMP, which is a secondary messenger known to activate PKA. The activation of PKA can result in the phosphorylation of transcription factors, which may include PHTF1, thus potentially enhancing its transcriptional activity.
The chemical PMA activates PKC, which is known for its role in the phosphorylation of proteins, including transcription factors. This post-translational modification can lead to the activation of transcription factors and potentially increase the functional activity of PHTF1. Ionomycin, by raising intracellular Ca²⁺ levels, activates calmodulin-dependent kinases, which can then phosphorylate transcription factors, suggesting a potential enhancement of PHTF1's functional activity through such signaling events.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases intracellular cAMP levels by activating adenylate cyclase, enhancing PKA activity. This kinase can phosphorylate transcription factors, potentially enhancing PHTF1 activity by promoting its transcriptional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can phosphorylate and activate transcription factors, suggesting a potential enhancement of PHTF1 activity through phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Elevates intracellular calcium levels, which can activate Calmodulin-dependent kinases that may, in turn, phosphorylate and activate transcription factors, thereby potentially enhancing PHTF1 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A natural polyphenol that may modulate signaling pathways and transcription factors by inhibiting DNA methyltransferases and HDACs, potentially enhancing PHTF1 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Binds to nuclear receptors which can heterodimerize with other transcription factors, possibly enhancing PHTF1 activity by promoting transcriptional regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Modulates multiple signaling pathways and may enhance transcription factor activity by inhibiting NF-κB, potentially reducing competition for coactivators that PHTF1 may require. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates sirtuin pathways that influence chromatin structure and transcription factor activity, potentially enhancing PHTF1 function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
An HDAC inhibitor that can lead to chromatin remodeling and enhanced access of transcription factors to DNA, potentially including PHTF1. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Induces autophagy and can lead to degradation of repressive chromatin-modifying proteins, potentially enhancing transcription factor access to DNA, including PHTF1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits glycogen synthase kinase 3 (GSK-3), which can lead to enhanced activity and stability of transcription factors, potentially benefiting PHTF1 activity. | ||||||