PHTF1 Inhibitors
PHTF1 inhibitors, as a chemical class, encompass a range of compounds that exert their effects on the protein indirectly by targeting various cellular processes and pathways involved in gene transcription. These inhibitors work by modulating the environment in which PHTF1 operates, rather than binding directly to the protein itself. For instance, some members of this class influence the transcriptional machinery by inhibiting RNA polymerase II, the enzyme responsible for synthesizing mRNA from DNA templates. This action results in a broad suppression of gene transcription, which can include the downregulation of genes that are normally under the control of PHTF1. Other inhibitors in this class target the chromatin structure and histone-modifying enzymes, altering the epigenetic landscape. By changing the acetylation status of histones, they can affect the accessibility of PHTF1 to its DNA binding sites. If the chromatin becomes too condensed or, conversely, too relaxed, it may prevent PHTF1 from effectively engaging with its target genes.
Additionally, some chemicals classified as PHTF1 inhibitors work by binding to DNA and obstructing the transcription initiation complex, thereby preventing the transcription of genes across the board, including those regulated by PHTF1. Others bind to specific DNA sequences or structures, potentially competing with PHTF1 for its DNA binding sites. There are also compounds that disrupt the normal signaling pathways that PHTF1 might rely on for its activity. For example, inhibitors that prevent the proper functioning of proteins involved in signaling cascades can lead to a decrease in the transcriptional activity of PHTF1 by indirectly reducing its activation or by limiting the availability of essential cofactors. The intricacy of these interactions underscores the complex nature of transcription regulation and highlights the indirect methods by which PHTF1's activity can be modulated. The compounds classified as PHTF1 inhibitors operate within these multifaceted networks, influencing PHTF1 by altering the cellular milieu in which it functions, thus providing a range of mechanisms by which the expression and function of PHTF1 can be indirectly controlled.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide has been shown to inhibit RNA polymerase II, a key enzyme in the transcription process. Since PHTF1 is a transcription factor, triptolide could impede PHTF1's function by preventing the transcription of its target genes. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-amanitin binds strongly to RNA polymerase II, inhibiting its transcriptional activity. By doing so, it could indirectly inhibit PHTF1 by suppressing the transcription of genes that PHTF1 would normally regulate. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA at the transcription initiation complex and prevents the elongation of RNA chains by RNA polymerase. This action could block PHTF1-mediated gene transcription by physically obstructing the interaction between PHTF1 and DNA. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA and preferentially interacts with G-C rich regions, potentially competing with or obstructing the DNA binding domain of PHTF1, thereby inhibiting its ability to regulate gene expression. | ||||||
MCC950 sodium salt | 256373-96-3 | sc-505904 sc-505904A sc-505904B sc-505904C | 5 mg 10 mg 50 mg 100 mg | $112.00 $194.00 $871.00 $1538.00 | 3 | |
ICG-001 selectively binds to CREB-binding protein (CBP), disrupting its interaction with β-catenin. If PHTF1's activity is modulated by CBP or Wnt/β-catenin signaling, ICG-001 could indirectly inhibit PHTF1's regulatory functions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor that can increase histone acetylation, potentially altering the chromatin structure and accessibility for transcription factors like PHTF1, thereby influencing its function. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 inhibits the histone acetyltransferase activity of p300/CBP, which could reduce the acetylation levels of histones associated with PHTF1 target genes, potentially hindering PHTF1's ability to activate those genes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA, like Trichostatin A, inhibits HDACs, leading to an open chromatin state. While this generally activates gene transcription, it could also disrupt specific PHTF1-DNA interactions if PHTF1 requires a particular chromatin structure to bind effectively. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR, sirolimus affects many cellular processes, including protein synthesis. If PHTF1 requires mTOR signaling for its synthesis or activation, sirolimus could reduce PHTF1 levels or activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to DNA demethylation. If gene loci regulated by PHTF1 are normally silenced by methylation, 5-Azacytidine could reactivate them, potentially counteracting PHTF1's repressive effects. | ||||||