PHLDA3 Activators
PHLDA3 Activators are largely characterized by their ability to induce endoplasmic reticulum (ER) stress or to regulate autophagy. Compounds like Thapsigargin, Tunicamycin, Dithiothreitol (DTT), and 2-Deoxy-D-glucose (2-DG) can induce ER stress, which in turn activates the transcription factor ATF4. ATF4 binding to the PHLDA3 promoter leads to its increased expression.
PHLDA3 activation via their influence on autophagy. Rapamycin, a known autophagy inducer, and 3-Methyladenine (3-MA) and Bafilomycin A1, autophagy inhibitors, can potentially affect PHLDA3 expression. Understanding the exact mechanisms and implications of these effects forms an active area of research. Similarly, the role of chemical chaperones like Tauroursodeoxycholic Acid (TUDCA) and Phenylbutyric Acid (4-PBA), which reduce ER stress, in PHLDA3 activation is an interesting research direction. Lastly, glucose and palmitic acid, a saturated fatty acid, can induce PHLDA3 expression via ATF4, underscoring the protein's role in metabolic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
High glucose levels can induce PHLDA3 expression through the activation of the transcription factor ATF4, which then binds to the PHLDA3 promoter. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic acid, a saturated fatty acid, has been shown to induce PHLDA3 expression via ATF4 in pancreatic beta cells. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin causes endoplasmic reticulum stress, which can lead to the activation of ATF4 and subsequently increase PHLDA3 expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin leads to endoplasmic reticulum stress, which can activate ATF4 and result in increased PHLDA3 expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-DG, a glucose analog, induces endoplasmic reticulum stress, leading to ATF4 activation and increased PHLDA3 expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
H2O2 can induce oxidative stress, which can lead to the activation of ATF4 and increase PHLDA3 expression. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
TUDCA is a chemical chaperone that helps reduce endoplasmic reticulum stress, potentially leading to reduced PHLDA3 expression. | ||||||
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
4-Phenylbutyric acid is another chemical chaperone that can reduce endoplasmic reticulum stress, potentially leading to reduced PHLDA3 expression. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-MA inhibits autophagy, a process that could potentially regulate PHLDA3 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin induces autophagy, which could potentially regulate PHLDA3 expression. | ||||||