PHC3 inhibitors represent a specialized class of chemical compounds characterized by their ability to intricately disrupt the functional activity of the Polyhomeotic homolog 3 (PHC3) protein. This protein assumes a pivotal role in orchestrating a range of essential cellular mechanisms, particularly those pertaining to epigenetic modulation and meticulous control over gene expression dynamics. The inhibitors within this chemical class exhibit a distinct mode of action, centered around their precise targeting of the enzymatic functionalities inherent to PHC3 or its intricate protein complexes. This intricate targeting strategy serves to intricately disrupt the customary epigenetic modifications, most notably histone methylation, which PHC3 significantly influences.
The core principle behind PHC3 inhibitors is their adeptness at modulating the intricate interactions that transpire between PHC3 and its intricate web of binding partners. This modulation, in turn, exerts a transformative impact on the broader landscape of gene expression patterns. The structural framework of PHC3 inhibitors is notably diverse, as it accommodates the requisite binding affinity and meticulous selectivity needed to precisely engage the target PHC3 protein or its array of interactive counterparts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is a small molecule inhibitor that targets the histone methyltransferase complex PRC2, which is associated with PHCBy inhibiting PRC2, UNC1999 disrupts the epigenetic regulation of gene expression. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
GSK126 is a inhibitor of PRC2 that affects histone methylation, including the methylation catalyzed by PHCIt. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438 is a selective inhibitor of the histone methyltransferase EZH2, a component of the PRC2 complex. Inhibition of EZH2 indirectly affects PHC3 and its epigenetic functions. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
GSK343 is a potent and selective inhibitor of the histone methyltransferase EZH2, which is closely linked to PHC3 function in the PRC2 complex. | ||||||
SP2509 | 1423715-09-6 | sc-492604 | 5 mg | $284.00 | ||
SP-2509 is a small molecule inhibitor that targets the PRC2 complex, which includes PHCIt has been explored for its potential in reversing aberrant gene silencing in various diseases. | ||||||
CPI-360 | 1802175-06-9 | sc-507464 | 1 mg | $100.00 | ||
CPI-360 is an inhibitor of the histone methyltransferase EZHIts mechanism of action involves disrupting the epigenetic regulation of gene expression, which includes the function of PHC3. | ||||||