PGP Substrates
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
Vinblastine Sulfate is a complex alkaloid that exhibits unique interactions with microtubules, disrupting their polymerization and leading to cell cycle arrest. Its distinct structural features allow for specific binding to tubulin, influencing the dynamics of cytoskeletal organization. The compound's reaction kinetics demonstrate a rapid onset of action, with a notable affinity for the P-glycoprotein transport system, impacting cellular efflux mechanisms and contributing to its pharmacokinetic profile. | ||||||
Vincristine Sulfate | 2068-78-2 | sc-201434 sc-201434A | 5 mg 25 mg | $122.00 $342.00 | 15 | |
Vincristine Sulfate is a potent alkaloid characterized by its intricate binding affinity to tubulin, which alters microtubule dynamics and impedes cellular mitosis. Its unique stereochemistry facilitates selective interactions with the P-glycoprotein transport system, enhancing its role in modulating drug resistance. The compound's kinetic behavior reveals a swift engagement with cellular targets, influencing intracellular transport and contributing to its distinct biochemical pathways. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin exhibits a remarkable affinity for P-glycoprotein, influencing its transport dynamics across cellular membranes. This compound's unique structural features enable it to engage in specific hydrogen bonding and hydrophobic interactions, which modulate its bioavailability. Its reaction kinetics suggest a complex interplay with efflux mechanisms, potentially altering the pharmacokinetic profiles of co-administered compounds. The distinct molecular interactions highlight its role in cellular transport processes. | ||||||
Mevinolinic acid, monoammonium salt | 77550-67-5 | sc-221939 | 100 mg | $1980.00 | ||
Mevinolinic acid, monoammonium salt, demonstrates intriguing interactions with P-glycoprotein, impacting its transport efficiency. The compound's unique ionic and polar characteristics facilitate specific binding to the protein, influencing substrate recognition and efflux activity. Its kinetic behavior reveals a nuanced relationship with membrane permeability, potentially affecting the distribution of various compounds. These molecular dynamics underscore its significance in modulating transport pathways within cellular environments. | ||||||