Pex13p Activators

**Pex13p activators** are a class of compounds that enhance the expression or activity of the Pex13p protein. Pex13p is a peroxisomal membrane protein that plays a crucial role in the import of proteins into peroxisomes. Pex13p activators can increase the levels of Pex13p protein, promote its interaction with other proteins, or enhance its activity in the import of proteins into peroxisomes.

Pex13p activators exert their effect by modulating different aspects of Pex13p biology. Some Pex13p activators, such as long-chain fatty acids (oleic acid, linoleic acid, palmitic acid, stearic acid, myristoleic acid, palmitoleic acid), induce Pex13p expression by activating the Pex3p transcription factor. Other Pex13p activators, such as mTOR inhibitors (rapamycin, torin 1, AZD8055, everolimus, sirolimus), induce Pex13p expression by inhibiting the mTOR signaling pathway. Additionally, lithium chloride, an inhibitor of glycogen synthase kinase-3 (GSK-3), can also induce Pex13p expression by inhibiting GSK-3. By modulating Pex13p expression or activity, Pex13p activators can influence the import of proteins into peroxisomes and thereby affect various cellular processes, including lipid metabolism, reactive oxygen species detoxification, and cell signaling. These compounds have been instrumental in dissecting the molecular mechanisms underlying Pex13p function and its involvement in various cellular processes.