PEMT Inhibitors
The chemical class of PEMT inhibitors encompasses compounds designed to directly or indirectly modulate the activity of phosphatidylethanolamine N-methyltransferase (PEMT), a critical enzyme in phospholipid metabolism. A myriad of indirect inhibitors, including 3-Deazaadenosine, Trimethylamine N-Oxide (TMAO), Homocysteine, 5-Aza-2'-deoxycytidine, Ursodeoxycholic Acid (UDCA), Guanidinoacetate, L-Carnitine, and Dimethylglycine (DMG), operate through diverse mechanisms linked to methyl group donation, choline metabolism, and epigenetic regulation. Betaine, for instance, actively participates in the BHMT pathway, indirectly regulating the methylation status of phosphatidylethanolamine.
The multifaceted actions of these compounds collectively present a nuanced and comprehensive view of potential regulators intricately woven into the complex web of cellular processes governing phospholipid metabolism. The interplay of these modulators provides valuable insights into the intricate regulatory mechanisms underlying PEMT activity. Understanding the intricate interactions within this chemical class is indispensable for elucidating the regulation of PEMT within the broader context of cellular pathways. The complexity of these interrelations underscores the need for a holistic comprehension of the multifaceted processes governing phospholipid metabolism. These findings contribute to the foundational knowledge necessary for unraveling the intricate regulatory network that governs PEMT activity, paving the way for further investigations into the finely tuned orchestration of phospholipid metabolism within the intricate landscape of cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Acetylpyrrole | 1072-83-9 | sc-237896 | 5 g | $37.00 | ||
3-Deazaadenosine, an adenosine analog, indirectly modulates PEMT by affecting the availability of SAM. By interfering with the methylation cycle, it can impact the generation of methyl donors for phosphatidylcholine synthesis. This indirect modulation may alter PEMT activity, influencing the methylation status of phosphatidylethanolamine and, consequently, cellular membrane properties. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Homocysteine, an amino acid, indirectly influences PEMT by participating in the methionine cycle. As a product of SAM-dependent methylation reactions, its accumulation can impact SAM availability for phosphatidylcholine synthesis. This indirect modulation may alter PEMT activity, affecting the methylation status of phosphatidylethanolamine and, consequently, cellular membrane composition and function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, indirectly modulates PEMT by influencing global DNA methylation patterns. By altering DNA methylation status, it can impact the expression of genes involved in phosphatidylcholine synthesis, including PEMT. This indirect modulation may influence cellular membrane composition and function, suggesting a potential link between epigenetic regulation and PEMT activity in the context of phospholipid metabolism. | ||||||
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $51.00 $128.00 | 4 | |
Ursodeoxycholic Acid (UDCA), a bile acid, indirectly modulates PEMT by affecting choline metabolism. By reducing the secretion of bile acids into the intestine, it may enhance choline availability for phosphatidylcholine synthesis via PEMT. This indirect modulation may impact cellular membrane composition and function, suggesting a connection between bile acid metabolism, choline utilization, and PEMT-mediated phospholipid synthesis. | ||||||
Guanidinoacetic Acid | 352-97-6 | sc-211571 sc-211571A sc-211571B | 25 mg 1 g 5 g | $166.00 $217.00 $273.00 | ||
Guanidinoacetate, a precursor for creatine synthesis, indirectly modulates PEMT by influencing methionine metabolism. By competing with homocysteine for methylation reactions, it can alter SAM availability for phosphatidylcholine synthesis. This indirect modulation may impact PEMT activity, affecting the methylation status of phosphatidylethanolamine and, consequently, cellular membrane composition and function. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
L-Carnitine, a quaternary ammonium compound, indirectly modulates PEMT by influencing choline metabolism. By competing with choline for transport into cells, it may affect choline availability for PEMT-mediated phosphatidylcholine synthesis. This indirect modulation may alter cellular membrane composition and function, suggesting a potential interplay between L-Carnitine metabolism, choline utilization, and PEMT activity in the context of phospholipid homeostasis. | ||||||