PEG Linkers

Octaethylene glycol serves as an effective PEG linker, distinguished by its long hydrophilic chain that enhances water solubility and biocompatibility. Its structure allows for strong hydrogen bonding, promoting stability in complex environments. The linker’s multiple hydroxyl groups enable versatile functionalization, facilitating the formation of diverse conjugates. Furthermore, its flexible backbone contributes to optimal spatial orientation, which is essential for achieving specific interactions in various chemical contexts.

Biotin-PEG11-azide is a specialized PEG linker characterized by its unique azide functional group, which enables efficient click chemistry reactions. This compound exhibits excellent solubility in aqueous environments due to its extended polyethylene glycol chain, promoting favorable molecular interactions. The biotin moiety facilitates strong binding to streptavidin, enhancing specificity in conjugation applications. Its flexible structure allows for dynamic conformational changes, optimizing reactivity and compatibility in diverse chemical systems.

Fluorescein-PEG4-acid is a versatile PEG linker distinguished by its carboxylic acid functionality, which enhances solubility and reactivity in various chemical environments. The fluorescein moiety provides strong fluorescence properties, enabling effective tracking and visualization in conjugation studies. Its four-unit PEG spacer offers flexibility, facilitating optimal molecular interactions and improving the kinetics of reactions. This compound's unique structure supports diverse applications in bioconjugation and labeling.

Chloroacetamido-PEG2-NHS ester is a specialized PEG linker characterized by its reactive N-hydroxysuccinimide (NHS) group, which promotes efficient coupling with amine-containing molecules. The chloroacetamido moiety enhances stability and selectivity in conjugation reactions, while the two-unit PEG spacer provides a balance of flexibility and solubility. This compound's unique reactivity profile allows for precise control over bioconjugation processes, facilitating tailored molecular interactions.

TAMRA-PEG4-DBCO is a versatile PEG linker featuring a dibenzocyclooctyne (DBCO) moiety, known for its rapid and selective click chemistry with azide-functionalized partners. The four-unit PEG spacer enhances solubility and biocompatibility, while maintaining a flexible structure that minimizes steric hindrance. This compound's unique reactivity enables efficient formation of stable conjugates, making it ideal for applications requiring precise molecular assembly and functionalization.

m-PEG12-t-butyl ester is a specialized PEG linker characterized by its t-butyl ester group, which enhances hydrophobic interactions and solubility in organic solvents. The twelve-unit PEG chain provides significant flexibility, facilitating efficient molecular interactions and reducing steric hindrance. This compound exhibits unique reactivity patterns, allowing for controlled release and functionalization in various chemical environments, making it a valuable tool for precise molecular engineering.

Biotin-PEG-NHS-5000Da is a versatile PEG linker featuring a biotin moiety that enables strong affinity for streptavidin and other biotin-binding proteins. The 5000 Da PEG chain enhances solubility and biocompatibility, while the NHS group facilitates efficient conjugation to amine-containing molecules. This compound exhibits rapid reaction kinetics, promoting stable linkages in diverse environments, and its unique structure allows for tailored modifications in bioconjugation applications.

Methyl-(PEG)4-NHS is a specialized PEG linker characterized by its unique four-unit polyethylene glycol chain, which enhances solubility and flexibility in conjugation reactions. The NHS ester group enables efficient coupling with amine functionalities, promoting rapid and selective reactions. This compound's hydrophilic nature reduces non-specific interactions, while its modular design allows for diverse functionalization, making it ideal for creating stable bioconjugates in various applications.

Endo-BCN-PEG2-acid is a specialized PEG linker characterized by its unique cyclooctyne structure, which enables strain-promoted azide-alkyne cycloaddition reactions. This linker exhibits enhanced solubility and flexibility due to its short polyethylene glycol chain, facilitating efficient conjugation with azide-containing partners. Its acidic functional group contributes to improved reactivity and stability in aqueous environments, promoting effective molecular interactions and minimizing non-specific binding.

Endo-BCN-PEG4-acid is a versatile PEG linker distinguished by its elongated polyethylene glycol chain, which enhances solubility and biocompatibility. The presence of the acidic moiety allows for effective modulation of pH-dependent interactions, promoting selective binding and stability in various environments. Its unique structure supports efficient click chemistry, particularly in facilitating rapid and specific conjugation reactions, while minimizing steric hindrance and promoting favorable reaction kinetics.