PDE4A Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ibudilast | 50847-11-5 | sc-203080 | 10 mg | $214.00 | 1 | |
Ibudilast functions as a selective phosphodiesterase 4A (PDE4A) inhibitor, characterized by its ability to stabilize the enzyme's conformation through specific electrostatic interactions and hydrophobic regions. This binding alters the enzyme's kinetics, effectively reducing the hydrolysis of cyclic AMP and cyclic GMP. Its unique structural features promote distinct allosteric modulation, influencing downstream signaling cascades and cellular responses, thereby enhancing the complexity of intracellular communication. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective PDE4 inhibitor, directly inhibits PDE4A, reducing cAMP hydrolysis. | ||||||
Sericic acid | 55306-03-1 | sc-396534 sc-396534A | 5 mg 25 mg | $122.00 $490.00 | ||
Sericic acid exhibits unique properties as a phosphodiesterase 4A (PDE4A) inhibitor, primarily through its capacity to form hydrogen bonds and engage in π-π stacking interactions with the enzyme's active site. This interaction leads to a conformational shift that modulates the enzyme's catalytic efficiency, impacting the degradation rates of cyclic nucleotides. Its distinct molecular architecture facilitates selective binding, influencing various signaling pathways and cellular dynamics. | ||||||
Roflumilast | 162401-32-3 | sc-208313 | 5 mg | $59.00 | 21 | |
Another selective PDE4 inhibitor, directly targets PDE4A, increasing intracellular cAMP levels. | ||||||
Apremilast | 608141-41-9 | sc-480062 | 5 mg | $444.00 | ||
A PDE4 inhibitor, directly acts on PDE4A, leading to elevated cAMP levels. | ||||||
2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine Hydrochloride | 153259-31-5 | sc-209157 | 100 mg | $320.00 | ||
Specifically inhibits PDE4, including PDE4A, altering cAMP metabolism. | ||||||
Piclamilast | 144035-83-6 | sc-478653 | 5 mg | $300.00 | ||
Directly inhibits PDE4A, influencing cAMP-dependent signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective PDE inhibitor, also affecting PDE4A among other PDEs, increasing cAMP levels. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
A non-selective PDE inhibitor with activity against PDE4A, increasing cAMP levels. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Mildly inhibits various PDEs including PDE4A, influencing intracellular cAMP levels. | ||||||