The chemical class known as PCDHAC1_Pcdhac1 Inhibitors is designed to selectively modulate the activity of the protocadherin alpha subfamily C member 1 (PCDHAC1 or Pcdhac1) protein. Protocadherins are a family of cell adhesion molecules involved in diverse cellular processes, particularly in neuronal development and synaptic plasticity. PCDHAC1, as a member of this subfamily, likely plays a role in mediating cell-cell interactions, contributing to the formation and maintenance of neuronal circuits. Inhibitors targeting PCDHAC1_Pcdhac1 operate by interfering with the normal functions of this protein, disrupting the intricate molecular interactions and signaling pathways in which PCDHAC1_Pcdhac1 is engaged. This interference may lead to alterations in cell adhesion patterns and could impact cellular communication processes governed by PCDHAC1_Pcdhac1.
The mechanism of action for PCDHAC1_Pcdhac1 inhibitors involves their selective binding to PCDHAC1_Pcdhac1, thereby modulating its activity and potentially influencing downstream cellular processes. These inhibitors could serve as valuable tools for researchers aiming to elucidate the specific functions of protocadherins within the broader context of cellular biology, particularly in the intricate processes of neuronal development and synaptic connectivity. The study of PCDHAC1_Pcdhac1 inhibitors contributes to our understanding of the regulatory mechanisms that govern cell adhesion and communication, providing insights into the complex molecular processes involved in the formation and maintenance of neuronal networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine inhibits the Hedgehog signaling pathway, which could indirectly influence the expression of various genes, including protocadherin family members. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 is a GSK-3 inhibitor, potentially affecting Wnt signaling and thereby altering the expression of certain genes. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV-939 inhibits Wnt/β-catenin mediated transcription, which could affect gene expression profiles including that of protocadherin genes. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
BIO is a GSK-3 inhibitor known to activate Wnt signaling, potentially leading to changes in gene expression patterns. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine is a DNA methyltransferase inhibitor that can lead to demethylation of genes and impact their expression. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT is a γ-secretase inhibitor, potentially altering Notch signaling and thereby affecting gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which could downregulate AKT/mTOR signaling, potentially leading to reduced protein synthesis and gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways and potentially affect transcription factors, leading to changes in gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to influence several signaling pathways and might modulate gene expression including that of protocadherins. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is known to affect the expression of genes involved in cellular defense mechanisms and may influence other gene expression pathways. | ||||||