patched 2 Activators

Patched 2 Activators consist of a variety of chemical compounds that enhance the functional activity of patched 2 through modulation of the Hedgehog (Hh) signaling pathway. Cyclopamine, a classic inhibitor of the pathway, binds directly to patched 2, which paradoxically leads to activation of the pathway by relieving the inhibition on Smoothened, consequently enhancing the activity of patched 2. In a similar vein, Purmorphamine and SAG, by acting as Smoothened agonists, enhance the functional activity of patched 2 through a feedback mechanism that is intrinsic to the Hh signaling pathway. Oxysterols such as 20(S)-Hydroxycholesterol and other sterol compounds like Cholesterol are known to engage with components of the Hh pathway, which includes interaction with Smoothened, thereby facilitating an increased activity of patched 2 through pathway dynamics.

Further, compounds such as SANT-1 and Itraconazole, though initially characterized as inhibitors of Smoothened, can lead to a compensatory upregulation of patched 2 due to the complex regulatory networks within the Hh pathway. GANT61, by disrupting GLI-mediated transcription, alters the pathway's dynamics, which could result in an indirect enhancement of patched 2 activity. Similarly, Jervine affects the pathway at the level of patched 2, potentially enhancing its activity. Compounds likeTomatidine and Vitamin D3, while not directly interacting with patched 2, modulate the Hh signaling pathway, indirectly influencing patched 2's role. This intricate interplay of pathway modulation by these activators underscores the sophisticated regulation of patched 2 activity, enabling precise control over its functional state without necessitating changes in its expression levels.