PARP-15 Inhibitors

PARP-15 inhibitors represent a class of chemical compounds designed to target and modulate the activity of the poly(ADP-ribose) polymerase 15 (PARP-15) enzyme. PARP-15 is a member of the PARP family of proteins, which play critical roles in DNA repair mechanisms within cells. These inhibitors are characterized by their ability to interfere with the catalytic function of PARP-15, thereby disrupting specific DNA repair pathways. The primary objective of PARP-15 inhibitors is to hinder the repair of damaged DNA strands in a precise manner.

The mechanism of action underlying PARP-15 inhibitors involves their interaction with the PARP-15 enzyme during DNA damage response. When DNA breaks occur, PARP-15 is one of the first responders at the site of damage. It recognizes DNA strand breaks and facilitates the repair process by adding poly(ADP-ribose) chains to target proteins. This modification recruits other repair proteins to the site. PARP-15 inhibitors disrupt this repair process by binding to the PARP-15 enzyme and blocking the synthesis of poly(ADP-ribose) chains. This interference leads to an accumulation of unrepaired DNA damage in the cell, ultimately resulting in genomic instability and cell death. PARP-15 inhibitors have garnered significant attention in the field of molecular biology and drug discovery due to their applications in cancer, as well as their involvement in DNA damage response pathways, making them valuable tools for studying DNA repair mechanisms and cellular responses to genotoxic stress. Researchers continue to explore the diverse chemical structures and properties of PARP-15 inhibitors, aiming to improve their selectivity and potency in targeting PARP-15 while minimizing off-target effects.