PAGE-4 Activators
The activators of PAGE-4 have been identified to influence its activity through modulation of various signaling pathways and cellular processes. One such mechanism involves the enhancement of intracellular messenger concentrations, leading to the activation of specific kinases that are capable of phosphorylating PAGE-4, thereby directly increasing its functional activity. These kinases, activated by elevated cyclic nucleotide levels, target PAGE-4 and related proteins, allowing for a more robust activation of the signaling cascade. This potentiation of PAGE-4's function is critical, considering its role within the cellular context. Another activation route is through the manipulation of intracellular calcium concentrations, which triggers a cascade of events involving calcium-dependent kinases. These kinases are known to phosphorylate substrates within their signaling pathways, which can include PAGE-4, thus enhancing its activity through this calcium-mediated signaling axis.
Further regulatory mechanisms include the inhibition of phosphatases that normally act to dephosphorylate and downregulate the activity of PAGE-4. By preventing the dephosphorylation of PAGE-4, these activators effectively maintain its phosphorylated, and thus active, state, prolonging its signaling activity and impact within the cell. Additionally, alterations in the balance of kinase and phosphatase activities can lead to compensatory responses within the cell. This can indirectly lead to the phosphorylation and subsequent activation of PAGE-4 through alternative signaling routes that are activated as a feedback mechanism to the primary signaling alterations.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and thereby increase the activity of PAGE-4 by enhancing its interaction with partner proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which may phosphorylate PAGE-4, leading to its enhanced functional activity. PKC-mediated signaling is known to regulate various proteins, and phosphorylation by PKC is a common method of activating protein functions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium levels, which can activate calcium/calmodulin-dependent protein kinases (CaMKs). These kinases can then phosphorylate PAGE-4, potentially increasing its functional activity through calcium-dependent signaling. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Inhibits phosphodiesterases, leading to increased cAMP levels, similarly activating PKA. PKA could then phosphorylate PAGE-4, leading to its activation through a cAMP-dependent pathway. | ||||||
Isoquinoline | 119-65-3 | sc-255224 sc-255224A | 5 g 100 g | $26.00 $58.00 | ||
Inhibits PKC, which can alter the balance of PKC-mediated pathways, indirectly activating PAGE-4 by reducing inhibitory phosphorylation events that may otherwise attenuate PAGE-4 activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that activates PKA. This can lead to the phosphorylation and activation of PAGE-4 if PAGE-4 is a PKA substrate in the cellular context, thus increasing PAGE-4 activity through a cAMP/PKA-dependent signaling mechanism. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium concentrations, potentially activating CaMKs. Activated CaMKs might phosphorylate PAGE-4, leading to its functional activation in calcium-dependent signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that activates PKA. Subsequent PKA-mediated phosphorylation could enhance PAGE-4 activity by promoting interactions with other proteins or modifying its conformation. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
Inhibits CaMKII, altering calcium signaling pathways. Through the inhibition of CaMKII, other calcium-dependent proteins may compensate and phosphorylate PAGE-4, leading to its activation in a feedback response to altered calcium signaling. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of many proteins. If PAGE-4 is regulated by dephosphorylation, inhibition of these phosphatases could result in enhanced PAGE-4 activity. | ||||||