P2Y4 Activators

P2Y4 Activators consist of various compounds that indirectly influence the functional activity of P2Y4 through modulation of purinergic signaling pathways and receptor-ligand interactions. Uridine Triphosphate (UTP), a natural ligand, and MRS4062, a selective agonist, activate P2Y4, leading to G-protein mediated signaling pathways such as PLC activation. This activation enhances P2Y4's role in cellular signaling and regulatory functions, including intracellular calcium mobilization. Suramin and Reactive Blue 2, acting as P2Y receptor antagonists, interact with P2Y4 and can alter receptor dynamics, potentially enhancing signaling pathways where P2Y4 is involved, particularly in cell communication and regulation. Further contributing to P2Y4 activation are compounds like PPADS, ATP, and BzATP. PPADS, another P2Y receptor antagonist, modulates P2Y4 activity and influences the receptor's signaling in cellular processes. ATP, an endogenous ligand, and BzATP, a P2X receptor agonist that also activates P2Y4, promote downstream signaling pathways, enhancing P2Y4's role in cell signaling, ion channel regulation, and neurotransmission. MRS2578, although a P2Y6 antagonist, can indirectly affect P2Y4 by modulating related purinergic signaling pathways. Similarly, Ap4A and Methylene ATP, as ligands for P2 receptors, can influence P2Y4 activity, potentially enhancing its role in signal transduction and inflammatory responses. Clopidogrel, an antiplatelet drug, and ARL67156, an ecto-ATPase inhibitor, also play roles in modulating P2Y4 activity. Clopidogrel's influence on P2Y receptors indirectly affects P2Y4, potentially enhancing its signaling in platelet aggregation and vascular functions, while ARL67156 increases extracellular ATP levels, enhancing P2Y4 activity by increasing ligand availability for receptor activation. These activators collectively underscore the intricate network of purinergic signaling and receptor interactions in which P2Y4 plays a pivotal role, highlighting the complexity of cellular communication mechanisms.