UTPγS trisodium salt (CAS 1266569-94-1)
QUICK LINKS
UTPγS trisodium salt is a nucleotide analogue used in molecular biology and biochemical research. This compound is a non-hydrolyzable mimic of uridine triphosphate (UTP) where the terminal phosphate has been modified with a thiophosphate group, rendering it resistant to enzymatic degradation. Consequently, UTPγS trisodium salt is instrumental in studies investigating the mechanism of action of various enzymes, such as kinases and phosphatases, that normally act on nucleotides. It is also utilized in the study of G protein-coupled receptors (GPCRs), particularly those that are activated by uracil nucleotides, to understand signal transduction pathways without the confounding effects of nucleotide hydrolysis. Moreover, UTPγS trisodium salt serves as a tool in the exploration of RNA synthesis and function, providing insights into transcription regulation and nucleotide-protein interactions.
UTPγS trisodium salt (CAS 1266569-94-1) References
- Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5'-O-thiodiphosphate and uridine 5'-O-3-thiotriphosphate. | Malmsjö, M., et al. 2000. J Pharmacol Exp Ther. 293: 755-60. PMID: 10869373
- The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. | Malmsjö, M., et al. 2000. Br J Pharmacol. 131: 51-6. PMID: 10960068
- Uridine nucleotide-induced stimulation of gluconeogenesis in isolated rat proximal tubules. | Mo, J. and Fisher, MJ. 2002. Naunyn Schmiedebergs Arch Pharmacol. 366: 151-7. PMID: 12122502
- The stable pyrimidines UDPbetaS and UTPgammaS discriminate between contractile cerebrovascular P2 receptors. | Malmsjö, M., et al. 2003. Eur J Pharmacol. 458: 305-11. PMID: 12504787
- Extracellular nucleotides induce vasodilatation in human arteries via prostaglandins, nitric oxide and endothelium-derived hyperpolarising factor. | Wihlborg, AK., et al. 2003. Br J Pharmacol. 138: 1451-8. PMID: 12721100
- Potent P2Y6 receptor mediated contractions in human cerebral arteries. | Malmsjö, M., et al. 2003. BMC Pharmacol. 3: 4. PMID: 12737633
- Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. | Wihlborg, AK., et al. 2006. Circ Res. 98: 970-6. PMID: 16543499
- Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. | Veit, G., et al. 2012. Mol Biol Cell. 23: 4188-202. PMID: 22973054
- Nucleotide modulates odor response through activation of purinergic receptor in olfactory sensory neuron. | Yu, Y. 2015. Biochem Biophys Res Commun. 463: 1006-11. PMID: 26072377
- Rho kinase activity governs arteriolar myogenic depolarization. | Li, Y. and Brayden, JE. 2017. J Cereb Blood Flow Metab. 37: 140-152. PMID: 26661251
- Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord. | Garcia, J., et al. 2017. Curr Biol. 27: 1982-1989.e3. PMID: 28648824
- UTP - Gated Signaling Pathways of 5-HT Release from BON Cells as a Model of Human Enterochromaffin Cells. | Liñán-Rico, A., et al. 2017. Front Pharmacol. 8: 429. PMID: 28751862
- TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy. | Sunggip, C., et al. 2018. Front Pharmacol. 9: 523. PMID: 29872396
- Absence of P2Y2 Receptor Does Not Prevent Bone Destruction in a Murine Model of Muscle Paralysis-Induced Bone Loss. | Agrawal, A., et al. 2022. Front Endocrinol (Lausanne). 13: 850525. PMID: 35721713
- Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. | Lazarowski, ER., et al. 1996. Br J Pharmacol. 117: 203-9. PMID: 8825364
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UTPγS trisodium salt, 1 mg | sc-204376 | 1 mg | $270.00 |