OTTMUSG00000005723 Activators

Interferon-gamma-inducible GTPase 10 (Gm12250) plays a crucial role in cellular immunity and is involved in various signaling pathways. It functions primarily as an immune response mediator, participating in the defense against intracellular pathogens. Gm12250 is activated through several mechanisms involving distinct chemical agents. One common mechanism involves the activation of Gm12250 through the SIRT1/AMPK pathway, as exemplified by resveratrol. Resveratrol enhances Gm12250 activity by promoting SIRT1 deacetylation, leading to the activation of AMPK and subsequent Gm12250 phosphorylation. Similarly, forskolin directly activates Gm12250 by stimulating adenylate cyclase, elevating cAMP levels, and subsequently triggering protein kinase A (PKA)-mediated Gm12250 activation. In another pathway, chemicals like TPA indirectly activate Gm12250 by activating protein kinase C (PKC), which can lead to the activation of MAPK pathways, ultimately phosphorylating Gm12250. Furthermore, compounds such as quercetin modulate Gm12250 through HDAC inhibition, increasing histone acetylation and promoting gene transcription. Sodium orthovanadate inhibits PTPs, leading to enhanced Gm12250 phosphorylation and activation.

Dexamethasone, by binding to glucocorticoid receptors, promotes Gm12250 gene transcription, resulting in increased expression of the protein. Compounds like 2-APB influence Gm12250 through calcium-dependent pathways by inhibiting IP3R and elevating intracellular calcium levels. Epinephrine activates Gm12250 through adrenergic receptor-mediated cAMP production and PKA activation. Additionally, thyroid hormone T3 activates Gm12250 by binding to thyroid hormone receptors and stimulating its gene transcription. Oleanolic acid inhibits NF-κB signaling, reducing the transcriptional repression of Gm12250. Salicylic acid modulates the NF-κB pathway, decreasing Gm12250 repression. Finally, curcumin interferes with the Wnt/β-catenin pathway, downregulating β-catenin and reducing the transcriptional repression of Gm12250. In summary, these chemical activators act through various pathways to enhance the functional activation of interferon-gamma-inducible GTPase 10 (Gm12250), contributing to its crucial role in cellular immunity.