OR5R1 Activators
OR5R1 include a variety of compounds that share the ability to bind to the protein's ligand-binding site and trigger a signaling cascade that results in the protein's activation. Isoamyl acetate, benzaldehyde, eugenol, anethole, citral, ethyl vanillin, geraniol, heptanal, hexanal, limonene, linalool, and methyl salicylate are among the odorant molecules that can perform this function. When these chemicals interact with OR5R1, they induce a conformational change in the protein's structure that leads to the activation of a G-protein. This G-protein then activates adenylate cyclase, an enzyme responsible for converting ATP to cAMP. As cAMP levels rise within the cell, they act as secondary messengers that activate protein kinase A (PKA), which then phosphorylates various target proteins, culminating in the activation of the OR5R1 protein.
The binding of these chemicals to OR5R1 is a crucial first step in the signal transduction process. For instance, isoamyl acetate, with its distinct banana-like smell, and benzaldehyde, known for its almond-like aroma, both can activate OR5R1 by fitting into its ligand-binding domain and initiating the signaling pathway. Similarly, eugenol, with its clove scent, and anethole, which has a licorice-like aroma, also activate OR5R1 through the same mechanism. Citrus-scented citral, vanilla-like ethyl vanillin, floral-scented geraniol, and other aldehydic molecules such as heptanal and hexanal, all engage with OR5R1's ligand-binding site to trigger the downstream signaling events. Limonene, with its citrusy smell, and linalool, which has a floral and spicy lavender odor, are both able to activate the OR5R1 protein by this well-characterized mechanism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate, through its odorant properties, activates OR5R1 by binding to the receptor's ligand-binding site, causing a conformational change that initiates the G-protein-coupled receptor signaling cascade, leading to an increase in intracellular cAMP levels, which in turn activates protein kinase A (PKA) and results in the activation of OR5R1. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol serves as an agonist to OR5R1 by docking at its ligand-binding site. This binding stimulates a G-protein-coupled response, which catalyzes the conversion of ATP to cAMP by adenylate cyclase. The elevated cAMP levels activate PKA, which then phosphorylates target proteins to produce a response, thereby activating OR5R1. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $565.00 $310.00 | ||
Anethole activates OR5R1 by binding to its specific odorant receptor site, causing a conformational change that triggers the associated G-protein to activate adenylate cyclase. This enzyme increases cAMP levels, which activate PKA and lead to the phosphorylation of proteins involved in the signaling pathway of OR5R1, culminating in its activation. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a citrus scent compound, binds to OR5R1, initiating a conformational alteration that activates the G-protein-coupled receptor pathway. The activation of adenylate cyclase and the subsequent rise in cAMP levels result in the activation of PKA. The cascade of events following PKA activation leads to the functional activation of OR5R1. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde activates OR5R1 by binding to its ligand-binding site, which stimulates the G-protein-coupled receptor mechanism, leading to the activation of adenylate cyclase. This causes an increase in cAMP, which activates PKA, and this activation sequence results in the activation of OR5R1. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol, a monoterpenoid and an alcohol, binds to OR5R1 and activates the receptor by inducing a conformational change that stimulates the G-protein to activate adenylate cyclase, increasing cAMP levels, thus leading to the activation of PKA and the consequent activation of OR5R1. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $29.00 $58.00 | ||
Heptanal interacts with OR5R1 by binding to its ligand-binding domain, which triggers the G-protein-coupled signaling pathway, leading to activation of adenylate cyclase. The increased production of cAMP activates PKA, which then leads to a series of phosphorylation events that activate OR5R1. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $26.00 | ||
Hexanal acts as an activator of OR5R1 by binding directly to the receptor's ligand-binding site, causing a conformational change that activates the G-protein signaling cascade. This leads to the activation of adenylate cyclase, an increase in cAMP levels, and activation of PKA, culminating in the activation of OR5R1. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
Limonene activates OR5R1 by binding to its ligand-binding site, inducing a G-protein-coupled receptor response that activates adenylate cyclase. The increase in cAMP levels triggers PKA activation, leading to downstream signaling events that activate OR5R1. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool activates OR5R1 by interacting with the receptor's ligand-binding site, which prompts the G-protein-coupled receptor pathway, leading to the activation of adenylate cyclase. The resulting rise in cAMP levels activates PKA, which in turn phosphorylates specific targets, resulting in the activation of OR5R1. | ||||||