OR52M1 Activators
OR52M1 include a variety of compounds that are commonly found in natural and synthetic fragrances. Isopentyl acetate, eugenol, and methyl salicylate are such compounds that engage this olfactory receptor through their binding to the odorant-binding site. This binding is a precise interaction that causes a change in the shape of OR52M1, which is the initial step in the olfactory signaling cascade. Similarly, benzaldehyde, a compound known for its almond-like aroma, and 2-heptanone, with its fruity scent, activate OR52M1 by binding to the receptor. This interaction induces a conformational change that is critical for the activation process. Phenethyl alcohol and limonene, the latter being a major component of citrus scents, also activate OR52M1 by binding to the ligand-binding domain of the protein, which is an essential step for the conformational change that triggers signal transduction.
Hexanal, citronellol, and 2-phenylethanol, each with distinct scents reminiscent of grass, roses, and floral notes, respectively, are also activators of OR52M1. Their activation mechanism involves the binding of these molecules to the specific odorant-binding sites on OR52M1, leading to the receptor's activation. Linalool, geraniol, and other similar scent molecules follow this same mode of action. Upon binding, OR52M1 undergoes a structural modification that is necessary for the initiation of the olfactory signaling pathway. This process is a crucial part of how the sense of smell works, translating chemical stimuli into a biological response. Each of these chemical activators contributes to the range of stimuli that OR52M1 can detect, exemplifying the diverse nature of odorant recognition by olfactory receptors.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
This compound is a known odorant that is detected by certain olfactory receptors, and while direct evidence for OR52M1 activation is not documented, related olfactory receptors are activated by specific odorants. As OR52M1 is an olfactory receptor, isopentyl acetate could directly activate OR52M1 by binding to its odorant-binding site, leading to a conformational change and initiation of the olfactory signaling cascade. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol is a constituent of various essential oils and has been shown to be an activator of certain olfactory receptors. It activates OR52M1 by interacting with the ligand-binding domain of the protein, which in turn triggers signal transduction mechanisms in olfactory sensory neurons. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate is a known plant-derived odorant that activates certain olfactory receptors. It activates OR52M1 by binding to the receptor's odorant recognition site, causing a shape change in the receptor that initiates a G-protein-coupled receptor signaling pathway. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone is a ketone with a fruity odor and activates olfactory receptors by binding to their odorant-binding region. This interaction with OR52M1 leads to activation of the receptor and subsequent olfactory signal transduction. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
Commonly found in floral fragrances, phenethyl alcohol activates olfactory receptors by binding to their specific odorant-binding sites. This binding to OR52M1 triggers a conformational change and activates the olfactory signaling pathway. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene is a citrus scent component that activates olfactory receptors by interacting with the ligand-binding domain. Activation of OR52M1 occurs when limonene binds to the receptor, leading to the initiation of the olfactory signal transduction cascade. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal is an aldehyde with a grassy odor, known to activate olfactory receptors. OR52M1 is activated by hexanal through its binding to the receptor's odorant-binding site, which causes a change in receptor conformation and initiates signal transduction. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol is a scent compound found in roses and geraniums that activates olfactory receptors. The activation of OR52M1 by citronellol involves the compound binding to the receptor's odorant-binding site, causing activation of the receptor and subsequent signaling. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, found in many flowers and spice plants, activates olfactory receptors. It activates OR52M1 by binding to its ligand-binding domain, causing a conformational change and the initiation of the olfactory signaling pathway. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a component of rose oil and palmarosa oil, activates olfactory receptors. It directly activates OR52M1 by binding to the receptor's specific odorant-binding site, triggering a conformational alteration and initiating the olfactory signal transduction mechanism. | ||||||