OR4C11 Activators

OR4C11 operate through a binding mechanism that initiates receptor activation. Isopentenyl pyrophosphate, a key intermediate in the biosynthesis of terpenoids and steroids, can interact with OR4C11, potentially triggering a conformational change that results in the receptor's activation. Similarly, adenine, which is a purine derivative, can serve as a ligand for OR4C11, initiating activation through its structural affinity for the binding site. Monoterpene derivatives such as geranyl acetate can directly interact with the ligand-binding site of OR4C11, leading to activation. Citronellol, a terpene alcohol, and eugenol, a phenylpropene, can also bind to OR4C11, which is consistent with the structural patterns observed in ligands that activate olfactory receptors.

Other chemicals like ionone, commonly found in floral fragrances, can serve as an activator of OR4C11 through specific interactions with the receptor's ligand-binding domain. Methyl anthranilate, used in flavorings and perfumes, can activate OR4C11 by binding to it, which is a recognized interaction pathway for olfactory receptors. Benzaldehyde, an aromatic aldehyde, can also activate OR4C11 by engaging with the receptor in a manner consistent with the activation of olfactory receptors. Terpene compounds such as limonene and alpha-terpineol can activate OR4C11 through direct binding. Similarly, linalool, a terpene alcohol present in many flowers and spice plants, can interact with and activate OR4C11. Lastly, farnesol, a sesquiterpene alcohol found in natural odors, can bind to and activate OR4C11 due to its structural compatibility, illustrating the diverse array of chemical interactions through which OR4C11 can be activated.