OR2D3 Activators
OR2D3 function through a series of molecular interactions that lead to the activation of this olfactory receptor. Compounds such as anethole, eugenol, and isoamyl acetate serve as ligands that bind to the specific domains of OR2D3. Upon binding, these chemicals induce a conformational change in the structure of OR2D3, which is the initial step in the receptor activation process. This structural alteration facilitates the coupling of OR2D3 with its associated G-protein, which is an essential component in the signal transduction pathway. The activation of the G-protein then leads to the production of the second messenger, cyclic AMP (cAMP), within the cell. The increase in intracellular cAMP levels is a clear indication that OR2D3 has been functionally activated by these chemicals.
Methyl salicylate, vanillin, and helional also participate in the receptor's activation, following a similar pattern of molecular engagement. Upon binding to OR2D3, these chemicals trigger the receptor's G-protein coupled signal transduction pathway. This results in the production of cAMP, signifying the activation of OR2D3. Other chemicals such as citral, benzaldehyde, cinnamaldehyde, geraniol, limonene, and alpha-ionone also demonstrate their ability to activate OR2D3 through this well-characterized mechanism. The binding of these various chemical activators to OR2D3 suggests a broad ligand specificity of this receptor, which is capable of responding to a wide array of chemical signals through a common pathway leading to its activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole is reported to be an activator of olfactory receptors, which includes the family of proteins that OR2D3 belongs to. This compound may activate OR2D3 by binding to its olfactory receptor domain, thus triggering the olfactory signaling cascade, which leads to increased intracellular levels of cAMP, and consequently, functional activation of OR2D3. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol is known to activate certain olfactory receptors. Given that OR2D3 is an olfactory receptor, eugenol can bind directly to the ligand-binding site of OR2D3, leading to a conformational change that activates the receptor's G-protein coupled signal transduction pathway, resulting in the production of cAMP, which is a direct measure of OR2D3 activation. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate has been identified as an activator for various olfactory receptors. By binding to the ligand-binding domain of OR2D3, isoamyl acetate may cause a conformational change in the protein structure, thereby activating the G-protein coupled receptor pathway and leading to an increase in intracellular cAMP, which is indicative of the functional activation of OR2D3. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate can activate olfactory receptors by binding to their ligand-binding domain. When bound to OR2D3, this compound can activate the receptor and its associated G-protein signaling pathway, culminating in elevated intracellular cAMP levels, which are a hallmark of OR2D3 activation. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin is another compound that activates olfactory receptors through direct binding. By interacting with OR2D3, vanillin may initiate the receptor's G-protein coupled signal transduction, leading to the production of cAMP and the subsequent activation of OR2D3. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral has affinity for olfactory receptors and upon binding to OR2D3, can act as an agonist, initiating the G-protein signaling cascade and resulting in cAMP production, which signifies the receptor's activation. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde binds and activates certain olfactory receptors. Interaction with OR2D3 can trigger its G-protein signaling pathway, culminating in cAMP production, a key indicator of OR2D3 activation. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol is capable of activating olfactory receptors by binding to them directly. This binding to OR2D3 can activate the receptor and its downstream G-protein signaling cascade, resulting in the production of cAMP, which serves as evidence of OR2D3's activation. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene, as an olfactory receptor agonist, can bind to OR2D3, initiating the G-protein coupled receptor signaling pathway and leading to an increase in intracellular cAMP, which marks the functional activation of OR2D3. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
Alpha-Ionone is known to act as an olfactory receptor agonist. By binding to OR2D3, it can activate the receptor, leading to the initiation of the G-protein signaling cascade and a subsequent rise in cAMP levels, signaling the activation of OR2D3. | ||||||