Date published: 2025-12-24

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OR2B11 Inhibitors

Chemical inhibitors of Olfactory Receptor 2B11 demonstrate a range of mechanisms by which they can directly inhibit the protein's function. Acetic Acid, for instance, interferes with the receptor's ligand binding site, blocking the binding of specific odorant molecules. This inhibition prevents the receptor from detecting and responding to olfactory stimuli. Similarly, Benzaldehyde and Cinnamic Aldehyde act by binding directly to the active site of Olfactory Receptor 2B11, thereby competing with natural ligands and effectively inhibiting the receptor's normal olfactory signal transduction. Eugenol, Isopentyl acetate, and Limonene follow a comparable inhibition strategy. They bind to the ligand-binding domain of Olfactory Receptor 2B11, which prevents the receptor from interacting with its specific odorant molecules. This process directly inhibits the receptor's ability to transduce olfactory signals. Further, Menthol, Methyl Salicylate, and 2-Phenylethanol exert their inhibitory effect on Olfactory Receptor 2B11 by competitively binding to its ligand-binding domain. This action blocks the interaction with natural odorant molecules, leading to a reduction in the receptor's olfactory signaling capacity. Vanillin, similarly, inhibits the receptor by occupying its active site, thus preventing natural odorant ligands from binding. Ethanol introduces a different inhibition mechanism; it alters the receptor's conformation through binding, disrupting its ability to bind to odorant molecules and inhibiting its function in olfactory signal transduction. Lastly, Citral acts as a competitive inhibitor by binding to the active site of Olfactory Receptor 2B11, which inhibits the receptor's interaction with natural odorant molecules and consequently its olfactory signaling function. Each of these chemicals, through their specific interaction with Olfactory Receptor 2B11, demonstrates a distinct yet effective approach to inhibiting the receptor's ability to detect and respond to olfactory stimuli.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Acetic acid

64-19-7sc-214462
sc-214462A
500 ml
2.5 L
$62.00
$104.00
5
(2)

Acetic Acid inhibits Olfactory Receptor 2B11 by interfering with the receptor's ligand binding site, preventing the binding of specific odorant molecules. This disruption directly inhibits the receptor's ability to detect and respond to olfactory stimuli.

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$102.00
$224.00
(0)

Cinnamic Aldehyde competes with natural ligands for the binding site of Olfactory Receptor 2B11, effectively inhibiting the receptor's normal function in olfactory signal transduction by preventing the binding of natural odorant molecules.

Eugenol

97-53-0sc-203043
sc-203043A
sc-203043B
1 g
100 g
500 g
$31.00
$61.00
$214.00
2
(1)

Eugenol inhibits Olfactory Receptor 2B11 by binding to its ligand-binding domain, which prevents the receptor from detecting and responding to its specific odorant molecules, thereby inhibiting its normal olfactory function.

Isopentyl acetate

123-92-2sc-250190
sc-250190A
100 ml
500 ml
$105.00
$221.00
(0)

Isopentyl acetate acts as an inhibitor to Olfactory Receptor 2B11 by occupying its binding site, which blocks the interaction with its natural odorant ligands and inhibits the receptor's ability to transduce olfactory signals.

D-Limonene

5989-27-5sc-205283
sc-205283A
100 ml
500 ml
$82.00
$126.00
3
(1)

Limonene binds to the active site of Olfactory Receptor 2B11, inhibiting the receptor's interaction with natural odorant molecules, thus directly inhibiting its olfactory signaling function.

(±)-Menthol

89-78-1sc-250299
sc-250299A
100 g
250 g
$38.00
$67.00
(0)

Menthol inhibits Olfactory Receptor 2B11 by binding to its ligand-binding site, which prevents the receptor from detecting and responding to odorant molecules, leading to an inhibition of its olfactory signal transduction.

Methyl Salicylate

119-36-8sc-204802
sc-204802A
250 ml
500 ml
$46.00
$69.00
(1)

Methyl Salicylate directly inhibits Olfactory Receptor 2B11 by binding to its active site, thereby blocking the interaction with its natural odorant ligands and inhibiting the receptor's ability to transduce olfactory signals.

2-Phenylethanol

60-12-8sc-238198
250 ml
$68.00
(0)

2-Phenylethanol inhibits Olfactory Receptor 2B11 by competitively binding to its ligand-binding domain, preventing the binding of natural odorant molecules and inhibiting the receptor's olfactory signaling function.

Vanillin

121-33-5sc-251423
sc-251423A
100 g
500 g
$43.00
$122.00
1
(1)

Vanillin acts as an inhibitor to Olfactory Receptor 2B11 by binding to its active site, thus preventing the receptor from interacting with its specific odorant ligands and inhibiting its olfactory signaling function.

Citral

5392-40-5sc-252620
1 kg
$212.00
(1)

Citral competitively inhibits Olfactory Receptor 2B11 by binding to its active site, which blocks the receptor's interaction with natural odorant molecules, leading to an inhibition of its olfactory signaling function.