OR10H3 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Sodium channel inhibitor that reduces sodium influx through epithelial sodium channels (ENaC). By inhibiting ENaC, amiloride may decrease intracellular sodium levels, which can indirectly inhibit OR10H3 by reducing the sodium-dependent depolarization of olfactory sensory neurons that express OR10H3. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $69.00 $110.00 | 4 | |
Thiourea derivative that inhibits the enzyme thyroid peroxidase, leading to decreased production of thyroid hormones. Lower thyroid hormone levels can indirectly inhibit OR10H3 by altering olfactory system sensitivity and potentially reducing the expression or function of olfactory receptors, including OR10H3. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Antimalarial drug that raises endosomal pH. It can affect the trafficking and recycling of G protein-coupled receptors (GPCRs), which may lead to decreased membrane expression and thus reduced functional activity of OR10H3, as it is a member of the GPCR family. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
A metal ion that can bind to and block ion channels. Copper's interaction with ion channels may affect the membrane potential and indirectly inhibit OR10H3 by modulating the excitability of olfactory sensory neurons. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Histamine H2 receptor antagonist that reduces gastric acid secretion. Cimetidine can also cross the blood-brain barrier and potentially affect central histaminergic pathways, which can indirectly influence the neuronal circuits where OR10H3 is expressed and decrease its functional activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Calcium channel blocker that inhibits L-type calcium channels. By reducing calcium influx, verapamil can decrease the activity of neurons and indirectly inhibit OR10H3 by affecting the excitability and signaling of neurons that express this olfactory receptor. | ||||||
Reserpine | 50-55-5 | sc-203370 sc-203370A | 1 g 5 g | $134.00 $406.00 | 1 | |
An alkaloid that depletes catecholamines and serotonin from neurons. This depletion can lead to reduced synaptic transmission, which may indirectly inhibit OR10H3 by affecting the olfactory bulb neurons that interact with OR10H3-expressing olfactory sensory neurons. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Benzothiazepine calcium channel blocker that inhibits L-type calcium channels. Similar to verapamil, diltiazem can decrease neuronal excitability, which could lead to indirect inhibition of OR10H3 by reducing signaling in olfactory sensory neurons. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Proton pump inhibitor that reduces gastric acid production by blocking H+/K+-ATPase in stomach parietal cells. While primarily affecting the stomach, omeprazole can alter systemic pH balance, which may indirectly affect the activity of GPCRs like OR10H3 in the olfactory system. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Metal ion that acts as an allosteric modulator of neurotransmitter receptors and can also block ion channels. Zinc's action can indirectly inhibit OR10H3 by altering the activity of neurons and the olfactory signal transduction pathway. | ||||||