OR10A4 Inhibitors
OR10A4 inhibitors comprise a range of compounds that interfere with specific biochemical pathways implicated in the regulation of OR10A4's function. These inhibitors act at various points in signaling cascades that could logically be linked to the functional activity of OR10A4. For instance, sodium orthovanadate, as a phosphatase inhibitor, could impede the dephosphorylation events that are essential for initiating a negative feedback loop that might result in the inhibition of OR10A4. Staurosporine, by broadly inhibiting protein kinases, would suppress the phosphorylation that is necessary for the activation of OR10A4. Brefeldin A, which disrupts protein trafficking to the membrane, would prevent OR10A4 from reaching the cell surface, thus inhibiting its functional expression.
Kinase inhibitors like genistein and the phospholipase C inhibitor U73122 can suppress key phosphorylation eventsand signaling molecules that may be required for OR10A4 activation. Similarly, PI3K inhibitors such as LY294002 and wortmannin would interfere with the PI3K/Akt pathway, which may be necessary for OR10A4's downstream signaling, leading to a reduction in its activity. Protein kinase C, which could be involved in OR10A4 modulation, would be inhibited by compounds like Go6983, thus potentially reducing OR10A4 activation. Inhibitors that affect the MAPK pathway, such as PD98059 for MEK and SB203580 for p38 MAPK, would decrease the pathway's activity that might otherwise culminate in OR10A4 activation. Additionally, the JNK pathway, if it plays a role in OR10A4 signaling, would be inhibited by SP600125, leading to a decrease in OR10A4 function. Lastly, NF449 specifically inhibits the Gs-alpha subunit of G-proteins; if OR10A4 signals through Gs protein, this would lead to a direct decrease in OR10A4-mediated signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is a phosphatase inhibitor that can prevent dephosphorylation of proteins within signaling pathways. If OR10A4 is involved in a phosphorylation-dependent signaling pathway, sodium orthovanadate could maintain the phosphorylation state of proteins upstream of OR10A4, leading to a sustained inhibition of OR10A4's activity via negative feedback mechanisms. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent kinase inhibitor that can inhibit a broad range of protein kinases. If OR10A4's function is regulated by phosphorylation through certain kinases, staurosporine could lead to decreased phosphorylation of OR10A4, resulting in its functional inhibition. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi apparatus function, which is crucial for protein trafficking to the membrane. For membrane proteins like OR10A4, Brefeldin A can inhibit its functional expression on the cell surface by blocking its trafficking pathway. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. If OR10A4 activity is modulated by tyrosine kinase pathways, genistein can inhibit these pathways, leading to reduced phosphorylation and activity of OR10A4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. If OR10A4 signaling involves PI3K/Akt pathway, then LY294002 would inhibit this pathway, leading to a decrease in OR10A4's downstream signaling activities. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor. Similar to LY294002, if OR10A4 function is dependent on the PI3K/Akt pathway, wortmannin would inhibit this pathway, resulting in decreased OR10A4 signaling. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go6983 is a protein kinase C inhibitor. If OR10A4's function is modulated by PKC-mediated phosphorylation, Go6983 can inhibit PKC activity, leading to a decrease in OR10A4 activation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK, which acts upstream of the ERK pathway. If OR10A4 is regulated by the ERK pathway, PD98059 could lead to reduced ERK pathway activity, thereby inhibiting OR10A4 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. If OR10A4 signaling is influenced by p38 MAPK, SB203580 would inhibit this pathway, which could lead to decreased activity of OR10A4. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of the JNK pathway. If OR10A4 is part of a signaling cascade that is regulated by JNK, SP600125 can inhibit JNK activity, thus decreasing OR10A4 signaling. | ||||||