Date published: 2026-5-11

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OPG Antibodies

Santa Cruz Biotechnology features a diverse variety of OPG monoclonal antibodies for investigating osteoprotegerin (OPG) in various biological processes. OPG Antibodies are validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA).Osteoprotegerin is a crucial regulator of bone metabolism, acting as a decoy receptor for RANKL, which is essential for osteoclast differentiation and activation. By inhibiting RANKL, osteoprotegerin plays a significant role in maintaining bone density and preventing excessive bone resorption. The importance of osteoprotegerin extends to various pathological conditions, including osteoporosis, cardiovascular diseases, and certain cancers, making it a vital target for therapeutic interventions. Understanding osteoprotegerin function has become increasingly important in developing treatments for bone disorders. Research into osteoprotegerin signaling pathways continues to reveal new insights about skeletal health and disease progression. Investigating osteoprotegerin regulation helps identify potential therapeutic targets for bone-related conditions.Santa Cruz Biotechnology monoclonal antibodies enable researchers to advance their understanding of bone remodeling mechanisms and contribute to breakthrough discoveries in medical research.

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OPG Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

OPG/Osteoprotegerin Antibody (E-10)

sc-390518mouse IgG1 κ153-401 (h)WB, IP, IF, ELISAm, r, h
29
(7)

OPG/Osteoprotegerin Antibody (4H219)

sc-71747mouse IgG120-37 (h)WB, IPh
4
(2)

OPG/Osteoprotegerin Antibody (TR1BK1)

sc-53976mouse IgG2a κFL (h)IP, ELISAh

new

(1)

OPG CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

OPG/Osteoprotegerin Double Nickase Plasmid (h)

sc-400497-NIChGene KnockoutPuromycin0
(0)

OPG/Osteoprotegerin Double Nickase Plasmid (h2)

sc-400497-NIC-2hGene KnockoutPuromycin0
(0)

OPG/Osteoprotegerin CRISPR/Cas9 KO Plasmid (m)

sc-422063mGene KnockoutGFP0
(0)

OPG/Osteoprotegerin HDR Plasmid (m)

sc-422063-HDRmHomology Directed RepairPuromycin0
(0)

OPG CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

OPG/Osteoprotegerin CRISPR Activation Plasmid (h)

sc-400497-ACThGene ActivationPuro, Blast, Hygro0
(0)

OPG/Osteoprotegerin CRISPR Activation Plasmid (h2)

sc-400497-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

OPG siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

OPG/Osteoprotegerin siRNA (h)

sc-40152hGene SilencingN/A
3
(0)

OPG/Osteoprotegerin shRNA Plasmid (h)

sc-40152-SHhGene SilencingPuromycin
3
(0)

OPG/Osteoprotegerin shRNA (h) Lentiviral Particles

sc-40152-VhGene SilencingPuromycin
3
(0)

OPG/Osteoprotegerin siRNA (m)

sc-40153mGene SilencingN/A
1
(0)

OPG/Osteoprotegerin shRNA Plasmid (m)

sc-40153-SHmGene SilencingPuromycin
1
(0)

OPG/Osteoprotegerin shRNA (m) Lentiviral Particles

sc-40153-VmGene SilencingPuromycin
1
(0)