OPG/Osteoprotegerin Antibody (4H219): sc-71747

OPG Antibody (4H219) is a mouse monoclonal IgG1 antibody that detects osteoprotegerin (OPG) in human samples through western blotting (WB) and immunoprecipitation (IP) applications. OPG plays a crucial role in bone metabolism by acting as a decoy receptor for RANKL (receptor activator of nuclear factor kappa-Β ligand), thereby inhibiting osteoclastogenesis and promoting bone density. This secreted glycoprotein is primarily located in the extracellular matrix and is produced by osteoblasts and other cell types, which is significant because OPG presence in the bone microenvironment is essential for regulating the balance between bone formation and resorption. By binding to RANKL, OPG prevents the activation of RANK on osteoclast precursors, effectively blocking their differentiation into mature osteoclasts, which are responsible for bone resorption. The regulation of OPG is also influenced by various cytokines, including TNFα and TNFβ, which can upregulate OPG expression, while prostaglandin E2 downregulates OPG, highlighting the complex interplay of signaling pathways that govern bone remodeling. Anti-OPG antibody (4H219) is therefore an invaluable tool for researchers studying bone biology and related disorders, providing insights into the mechanisms of osteoclast regulation and potential therapeutic targets for conditions such as osteoporosis.

The preferred OPG/Osteoprotegerin antibody is OPG/Osteoprotegerin Antibody (E-10): sc-390518.