Olfr993 Activators
Olfr993 is an olfactory receptor, part of the extensive G-protein-coupled receptor (GPCR) family, which plays a crucial role in the detection and interpretation of olfactory signals. These receptors are responsible for converting chemical stimuli from the environment into electrical signals that the brain interprets as distinct odors. The activation of Olfr993, as with other olfactory receptors, hinges on the specific binding of odorant molecules to the receptor. This binding triggers a series of conformational changes in Olfr993, essential for initiating downstream signaling pathways. Upon the binding of an odorant molecule, Olfr993 undergoes a structural alteration that enables its interaction with G-proteins. This interaction is vital for the receptor's activation, leading to the activation of adenylate cyclase, an enzyme responsible for converting ATP into cyclic AMP (cAMP). The increase in cAMP levels subsequently activates protein kinase A (PKA), which phosphorylates various cellular targets. This cascade of molecular events translates the chemical signal into a neuronal response, enabling the perception of smell. The specificity of ligand-receptor interactions in the olfactory system, as demonstrated by Olfr993 and its activators, underpins the complex and nuanced nature of odor detection and discrimination.
The study of Olfr993 and its activation mechanisms offers critical insights into the molecular basis of olfaction and broader GPCR signaling. This knowledge not only enhances our understanding of sensory biology but also has broader implications in physiology and pharmacology, as GPCRs are targets for various interventions. However, the focus here is on the basic science of how Olfr993 functions within the olfactory system. This perspective is fundamental to advancing our understanding of sensory systems and their role in interpreting external chemical cues.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr993 by binding to its orthosteric site, inducing a conformational change that facilitates G-protein coupling. This activation leads to adenylate cyclase stimulation, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr993. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate activates Olfr993 by binding to specific sites on the receptor, causing a conformational rearrangement. This rearrangement facilitates G-protein interaction and adenylate cyclase activation, increasing cyclic AMP production, leading to PKA activation and functional activation of Olfr993. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Olfr993 through allosteric modulation, altering its conformation to enable effective G-protein coupling. This stimulates adenylate cyclase, elevating cyclic AMP levels, and activating PKA, thereby functionally activating Olfr993. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr993 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr993. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Olfr993 by binding directly to the receptor, inducing a conformational change. This stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, increased cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr993. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates Olfr993 through its interaction with specific binding sites, inducing structural alterations. These alterations facilitate G-protein coupling, leading to adenylate cyclase stimulation, increased cyclic AMP production, and PKA activation, functionally activating Olfr993. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol activates Olfr993 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and activating PKA, thereby functionally activating Olfr993. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $51.00 | ||
Ethyl hexanoate activates Olfr993 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr993. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptaldehyde activates Olfr993 through direct interaction with its binding domain, triggering a structural change. This change enables G-protein coupling and adenylate cyclase activation, increasing cyclic AMP production and PKA activation, thereby functionally activating Olfr993. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates Olfr993 by interacting with specific binding sites on the receptor, leading to a conformational shift. This shift facilitates G-protein coupling and activation, triggering adenylate cyclase, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr993. | ||||||